{"product_id":"arid3a-antibody-at-rich-interactive-domain-containing-protein-3a-bha17135243","title":"ARID3A Antibody \/ AT-rich interactive domain-containing protein 3A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eARID3A Antibody \/ AT-rich interactive domain-containing protein 3A is a anti-ARID3A Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Flow cytometry (FACS), Immunoprecipitation (IP), Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ARID3A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e FACS, IP, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe ARID3A antibody targets AT-rich interactive domain-containing protein 3A, a nuclear transcription factor encoded by the ARID3A gene. Belonging to the ARID family of DNA-binding proteins, ARID3A regulates gene expression through chromatin remodeling and promoter activation. It binds specifically to AT-rich DNA sequences and modulates transcription during embryogenesis, hematopoietic development, and immune system differentiation. The ARID3A antibody enables researchers to study the protein's distribution, activity, and role in transcriptional networks that define cellular identity.\u003cbr\u003e\u003cbr\u003eAT-rich interactive domain-containing protein 3A plays an essential role in B-cell development and immunoglobulin gene transcription. It promotes accessibility of heavy-chain enhancer regions and is crucial for the proper differentiation of pre-B and mature B lymphocytes. The ARID3A antibody is widely used in immunology and developmental biology research to assess how ARID3A expression correlates with cell fate and lineage commitment. Alterations in its expression have been associated with autoimmune disorders, hematological malignancies, and aberrant immune signaling pathways.\u003cbr\u003e\u003cbr\u003eBeyond hematopoiesis, ARID3A contributes to embryonic patterning and organogenesis. It interacts with other chromatin regulators to influence developmental gene programs in neural and epithelial cells. Dysregulated expression can result in abnormal proliferation, reduced differentiation, and oncogenic transformation. The ARID3A antibody allows for high-resolution detection of this transcription factor in tissue and cell-based assays, helping define how ARID3A participates in chromatin remodeling, enhancer activation, and epigenetic memory.\u003cbr\u003e\u003cbr\u003eIn experimental use, the ARID3A antibody performs effectively in western blotting, immunofluorescence, chromatin immunoprecipitation, and immunohistochemistry. These applications reveal protein abundance, nuclear localization, and DNA-binding site occupancy. Through combination with transcriptomic analysis, the ARID3A antibody supports integrative studies of gene regulation, highlighting how AT-rich interactive domain-containing protein 3A interacts with co-factors to orchestrate transcriptional networks governing development and immunity.\u003cbr\u003e\u003cbr\u003eARID3A expression patterns are also linked to tumor progression and metastasis. Elevated or suppressed levels of the protein can influence tumor suppressor pathways and DNA repair mechanisms. The ARID3A antibody from \u003cbr\u003e\u003cbr\u003eBy facilitating the study of AT-rich interactive domain-containing protein 3A, the ARID3A antibody continues to advance molecular understanding of chromatin organization and gene regulation. Its value extends from developmental and immunological research to clinical oncology, where deciphering ARID3A function may lead to improved diagnostics and targeted therapies. The antibody's consistent performance makes it an essential reagent for decoding the transcriptional architecture underlying human biology and disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ARID3A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ARID3A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ARID3A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ARID3A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ARID3A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047284990317,"sku":"FY12340","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_31420a87-b448-42da-88d7-48726627caaf.jpg?v=1782236984","url":"https:\/\/www.ebiohippo.com\/products\/arid3a-antibody-at-rich-interactive-domain-containing-protein-3a-bha17135243","provider":"BioHippo","version":"1.0","type":"link"}