{"product_id":"arvanil-bhb21300022","title":"Arvanil","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (5Z,8Z,11Z,14Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]icosa-5,8,11,14-tetraenamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e N-Vanillylarachidonamide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 128007-31-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C28H41NO3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;96% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 nM - 1 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPV1 channels, CB1 receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Arvanil is an agonist of TRPV1 channels (EC50 = 0.5 nM), a ligand of CB1 receptors (Ki = 0.25-0.5 μM), and an inhibitor of anandamide accumulation (IC50 = 3.6 µM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice1-3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e N-Vanillylarachidonamide\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eArvanil (N-Vanillylarachidonamide) is an agonist of TRPV1 channels and a ligand of CB1 cannabinoid receptors. Arvanil is a structural hybridization between the arachidonoyl group of anandamide (CB1 receptor ligand) and the vanillyl moiety of capsaicin1,2. Arvanil shows an EC50 value of 0.5 nM for TRPV1 receptors, and an IC50 value of 3.6 µM as an inhibitor of anandamide accumulation1.Studies have found that arvanil has the ability to induce dose-dependent apoptosis in the lymphoid Jurkat T-cell line2.CB1 receptors are important regulators of excitatory and inhibitory synaptic transmission in different areas in the brain. The receptor plays a crucial role in multiple sclerosis disease course and in mood control3.TRPV1 receptors are highly expressed in primary nociceptors. These channels can be activated by several stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249705083245,"sku":"A-335-10MG-1","price":50.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311552455021,"sku":"A-335-100MG-1","price":355.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311552487789,"sku":"A-335-25MG-1","price":111.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311552520557,"sku":"A-335-50MG-1","price":202.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-335_gr.gif?v=1778544403","url":"https:\/\/www.ebiohippo.com\/products\/arvanil-bhb21300022","provider":"BioHippo","version":"1.0","type":"link"}