{"product_id":"ascl2-antibody-achaete-scute-homolog-2-bha17128189","title":"ASCL2 Antibody \/ Achaete-scute homolog 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eASCL2 Antibody \/ Achaete-scute homolog 2 is an antibody targeting \u003cstrong\u003eASCL2\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ASCL2.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eASCL2 belongs to a family of genes that are involved in determining cell fate and differentiation, particularly in the development of tissues such as the nervous system and the intestines. Studies have shown that ASCL2 plays a critical role in regulating the self-renewal and differentiation of stem cells, making it a key player in tissue regeneration and repair processes. One of the most fascinating aspects of ASCL2 is its ability to control the expression of other genes, essentially acting as a master regulator in the cellular development process. By activating or repressing specific genes, ASCL2 can influence the fate of a cell and dictate its ultimate function within a tissue or organ. ASCL2 has been implicated in a variety of diseases and conditions, including certain types of cancers where its dysregulation can lead to uncontrolled cell growth and proliferation.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q96QA5 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q96QA5 - Gene search: ASCL2 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ASCL2 - Ensembl search: ASCL2 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ASCL2 - PubMed search: ASCL2 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ASCL2+antibody - Reactome search: ASCL2 — Reactome — https:\/\/reactome.org\/content\/query?q=ASCL2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046409986413,"sku":"F55126-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046467887469,"sku":"F55126-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4912a277-5dfd-4604-a5d0-ec7e3faad0ab.jpg?v=1772000492","url":"https:\/\/www.ebiohippo.com\/products\/ascl2-antibody-achaete-scute-homolog-2-bha17128189","provider":"BioHippo","version":"1.0","type":"link"}