{"product_id":"atf4-antibody-bha10800657","title":"ATF4 antibody","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc ul{margin:0 0 12px;padding-left:22px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eTranscriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3\/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3\/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3\/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).\u003c\/p\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePolyclonal Rabbit Antibody\u003c\/span\u003e\n\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eELISA\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWestern Blot\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImmunohistochemistry\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImmunoprecipitation\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFlow Cytometry\u003c\/td\u003e\n\u003ctd\u003eRefer to datasheet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eImmunogen \u0026amp; Specificity\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e activating transcription factor 4(tax-responsive enhancer element B67)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt\/Swiss-Prot:\u003c\/strong\u003e \u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/P18848\" target=\"_blank\"\u003eP18848\u003c\/a\u003e\u003c\/p\u003e\n\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification Method\u003c\/th\u003e\n\u003ctd\u003eImmunogen Affinity Purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e≥95% as determined by SDS-PAGE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e50-58 kDa, 35-38 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003eConfirmed reactivity in \u003cstrong\u003eHuman, Mouse, Rat\u003c\/strong\u003e samples; validated for \u003cstrong\u003eELISA, Western Blot, Immunohistochemistry, Immunoprecipitation, Flow Cytometry\u003c\/strong\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFor Research Use Only (RUO). Not intended for diagnostic procedures.\u003c\/li\u003e\n\u003cli\u003eShipping: cold-chain shipment (typically with ice packs).\u003c\/li\u003e\n\u003cli\u003eUpon receipt: store at recommended temperature as soon as possible.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSales terms and conditions\u003c\/strong\u003e: Please review prior to ordering.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore additional antibodies and related detection reagents for \u003cstrong\u003eATF4\u003c\/strong\u003e in the BioHippo catalog.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Fine Test","offers":[{"title":"100 ug","offer_id":53327766454637,"sku":"FNab00662-100UG","price":312.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/antibody_afdf7bbd-05e9-41dd-867a-1d5076056ed5.jpg?v=1778727626","url":"https:\/\/www.ebiohippo.com\/products\/atf4-antibody-bha10800657","provider":"BioHippo","version":"1.0","type":"link"}