{"product_id":"atpa-bhb21300044","title":"ATPA","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-azaniumyl-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 140158-50-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C10H16N2O4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;96%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.5-50 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GluK1 (GluR5) kainate receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e ATPA is a potent and selective agonist of GluR5 kainate receptor (EC50 = 0.66 µM), inactive on GluR6 and less active on other kainate receptor subtypes. It is also a significantly weaker agonist of AMPA receptors (EC50 = 8 µM-62 µM, depending on subtype)1,2.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eATPA, an AMPA derivative, is a potent and selective agonist of the GluR5 (GluK1) kainate receptor subtype, with an EC50 value of 0.66 µM1. ATPA is less active towards other kainate receptor subtypes and is inactive towards GluR6. The compound also shows weak agonistic activities towards AMPA receptors1,2. Studies show that ATPA can induce clonic seizures when infused intravenously or directly into the rat amygdala3.GluR5 containing kainate receptors play an important role in the regulation of GABA(A) receptor-mediated inhibitory transmission in the hippocampus and in the amygdala3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249704427885,"sku":"A-480-10MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311550882157,"sku":"A-480-25MG-1","price":373.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311550914925,"sku":"A-480-5MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311550947693,"sku":"A-480-50MG-1","price":649.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-480_gr.gif?v=1778544421","url":"https:\/\/www.ebiohippo.com\/products\/atpa-bhb21300044","provider":"BioHippo","version":"1.0","type":"link"}