{"product_id":"az-10606120-dihydrochloride-bhb21300034","title":"AZ 10606120 dihydrochloride","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-(1-adamantyl)-N-[2-[2-(2-hydroxyethylamino)ethylamino]quinolin-5-yl]acetamide;dihydrochloride.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]- 2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 607378-18-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C25H36Cl2N4O2 (C25H34N4O2 · 2HCl).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;97%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e P2X7 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e AZ 10606120 dihydrochloride is a potent and selective non-competitive antagonist of P2X7 receptors, acting as a negative allosteric modulator shown to inhibit human P2X7 receptors with pIC50 of 8.1-8.91-3. It also inhibits growth and neoangiogenesis of P2X7-expressing tumors in mice4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]- 2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eAZ 10606120 dihydrochloride is a potent and selective noncompetitive antagonist of the P2X7 receptor with IC50 value of ~10 nM2. The compound shows little or no effect at other P2X receptor subtypes1,2. In studies conducted in animal models, AZ 10606120 treatment shows antidepressant effects and reduces tumor growth2.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. Seven members of this family have been identified and function in homomeric or heteromeric combinations. P2X7 receptor is a therapeutic target due to its potential involvement in pain and inflammatory disorders1,2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249704460653,"sku":"A-405-10MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311544066413,"sku":"A-405-25MG-1","price":373.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311544099181,"sku":"A-405-5MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311544131949,"sku":"A-405-50MG-1","price":672.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-405_gr.gif?v=1778544422","url":"https:\/\/www.ebiohippo.com\/products\/az-10606120-dihydrochloride-bhb21300034","provider":"BioHippo","version":"1.0","type":"link"}