{"product_id":"azasetron-bhb21300010","title":"Azasetron","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Y-25130\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 123040-93-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C17H20ClN3O3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e 5-HT3A, 5-HT3B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Azasetron is a potent and selective 5-HT3 channel blocker with Ki ~2.9 nM1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Y-25130\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eAzasetron is a potent and selective 5-HT3 receptor antagonist. It antagonizes the channel by binding to 5-HT3 receptors thereby blocking the serotonin binding site and antagonizing the indirect sympathomimetic responses to 5-HT3.The compound is classified as a derivative of benzamide with a longer duration of action and higher affinity than other 5-HT3 receptor antagonists.Azasetron is highly effective in preventing postoperative and chemotherapy-induced nausea and vomiting induced by anticancer drugs and radiotherapy1,2. Therefore, in most cases 5-HT3 receptor antagonists are co-administered with anticancer drugs3.The 5-HT3 receptor subtype is a member of the cys-loop ligand-gated cation channels expressed throughout the central and peripheral nervous systems and mediate a variety of important physiological functions4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249703772525,"sku":"A-240-10MG-1","price":254.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311546098029,"sku":"A-240-25MG-1","price":569.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311546130797,"sku":"A-240-5MG-1","price":151.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311546163565,"sku":"A-240-50MG-1","price":1019.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/A-240_gr.gif?v=1778544408","url":"https:\/\/www.ebiohippo.com\/products\/azasetron-bhb21300010","provider":"BioHippo","version":"1.0","type":"link"}