{"product_id":"ba-f3-cell-bhc11101407","title":"Ba\/F3 cell","description":"The BA\/F3 cell line, originating from murine pro-B cells of the BALB\/c mouse strain, is a cornerstone in drug discovery and development, where BaF3 cells are commonly used to test the efficacy of small molecule inhibitors targeting oncogenic kinases.\nBaf3 is an IL-3 dependent cell line with a single, round cell morphology and instances of polymorphism. Ba\/F3 cells are used for F3 transformation assays and Ba\/F3 proliferation assays. The F3 transformation assays allow for the exploration of how specific genetic alterations can confer IL-3 independent growth, indicating oncogenic potential. These cells rely on cytokine signaling through cytokine receptors for IL-3 to sustain their proliferation, making the baf3 proliferation assay an excellent tool for studying the effects of cytokine deprivation and the role of cytokine signaling in cell survival and growth.\nBA\/F3 cells have proven invaluable in the context of kinase oncogene evaluation and the testing of small-molecule kinase inhibitors. For instance, Ba\/F3 cells transformed to express the BCR-ABL oncogene, which is characteristic of chronic myeloid leukemia (CML), have been used to test the effectiveness of tyrosine kinase inhibitors (TKIs) such as imatinib. Ba\/F3 cells are further suitable for high-throughput screening and the exploration of drug resistance mechanisms, which are crucial in understanding the dynamics of cancer-associated kinome mutations and developing strategies to overcome resistance in targeted therapies.\nOverall, the BA\/F3 cell line, with its distinct features and biological functions, serves as a critical resource in kinase drug discovery.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101407\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950197928301,"sku":"305224","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/BA-F3_20P1_2020x01_20220124_ch00_1920x1920_2bcc28b3-88f9-4dfb-82c5-06b1121fad32.jpg?v=1769068953","url":"https:\/\/www.ebiohippo.com\/products\/ba-f3-cell-bhc11101407","provider":"BioHippo","version":"1.0","type":"link"}