{"product_id":"bbs1-antibody-bardet-biedl-syndrome-1-bha17135303","title":"BBS1 Antibody \/ Bardet-Biedl syndrome 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eBBS1 Antibody \/ Bardet-Biedl syndrome 1 is a anti-BBS1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e BBS1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe BBS1 antibody targets Bardet-Biedl syndrome 1 protein, a centrosomal and ciliary component encoded by the BBS1 gene. This protein is a core subunit of the BBSome, a multimeric complex required for the trafficking of membrane proteins to and from primary cilia. Bardet-Biedl syndrome 1 protein plays a crucial role in ciliary signaling, cell polarity, and sensory perception. The BBS1 antibody provides a key reagent for studying cilia function, intracellular transport, and ciliopathies associated with BBSome dysfunction.\u003cbr\u003e\u003cbr\u003eThe BBSome complex, composed of at least eight core proteins including BBS1, BBS2, BBS4, and BBS7, mediates cargo recognition and vesicular transport along the ciliary membrane. Bardet-Biedl syndrome 1 protein acts as a structural hub that anchors the complex to the basal body and interacts with small GTPases such as ARL6. The BBS1 antibody allows visualization of this component in centrosomes and cilia, supporting studies into how BBSome assembly regulates signaling receptor localization and function.\u003cbr\u003e\u003cbr\u003eMutations in BBS1 are the most common cause of Bardet-Biedl syndrome, a pleiotropic ciliopathy characterized by retinal degeneration, obesity, renal anomalies, and polydactyly. These mutations impair BBSome stability and disrupt ciliary transport of G-protein-coupled receptors (GPCRs). The BBS1 antibody supports functional research into these mechanisms by enabling analysis of protein expression, localization, and complex formation in patient cells and model organisms. It is a critical tool for defining how ciliary trafficking defects lead to multisystemic disease manifestations.\u003cbr\u003e\u003cbr\u003eBeyond ciliopathy research, Bardet-Biedl syndrome 1 protein has been implicated in metabolic regulation, immune signaling, and neural development. The BBS1 antibody supports studies exploring these expanded roles, including how BBSome components modulate leptin receptor and Hedgehog signaling pathways. Dysregulation of ciliary protein transport impacts sensory and hormonal signaling, linking BBS1 to diverse physiological processes.\u003cbr\u003e\u003cbr\u003eThe BBS1 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, revealing punctate centrosomal and ciliary staining patterns.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=BBS1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=BBS1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=BBS1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/BBS1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=BBS1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047287316845,"sku":"FY12400","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8b1c34f0-14c0-4cfb-82e7-697439ff3c67.jpg?v=1782237004","url":"https:\/\/www.ebiohippo.com\/products\/bbs1-antibody-bardet-biedl-syndrome-1-bha17135303","provider":"BioHippo","version":"1.0","type":"link"}