{"product_id":"bcap29-antibody-b-cell-receptor-associated-protein-29-bha17135336","title":"BCAP29 Antibody \/ B-cell receptor-associated protein 29","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eBCAP29 Antibody \/ B-cell receptor-associated protein 29 is a anti-BCAP29 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (ER).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e BCAP29\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe BCAP29 antibody targets B-cell receptor-associated protein 29, a membrane-associated chaperone encoded by the BCAP29 gene. B-cell receptor-associated protein 29 localizes mainly to the endoplasmic reticulum (ER) and Golgi apparatus, where it functions in protein trafficking, quality control, and ER-to-Golgi transport. It forms part of a complex with BCAP31, facilitating the export of membrane and secretory proteins. The BCAP29 antibody provides a powerful research tool for examining intracellular trafficking, membrane-protein maturation, and immune signaling. \u003cbr\u003e\u003cbr\u003eB-cell receptor-associated protein 29 contributes to proper folding and assembly of multimeric proteins in the ER. It interacts with several chaperone components, including Sec61 and calnexin, to ensure accurate post-translational processing before cargo delivery to the Golgi. The BCAP29 antibody supports localization studies demonstrating its distribution along ER membranes and cis-Golgi compartments. Through its cooperation with BCAP31, it links cargo transport with apoptotic signaling under stress conditions. \u003cbr\u003e\u003cbr\u003eIn B lymphocytes, B-cell receptor-associated protein 29 participates in antigen receptor processing and trafficking. The BCAP29 antibody enables investigation of these processes and provides insight into how ER quality control affects immune-receptor assembly. It is also expressed in non-immune cells, indicating a more general role in secretory-pathway regulation. Disruption of BCAP29 function has been associated with altered membrane trafficking and ER stress responses. \u003cbr\u003e\u003cbr\u003eEmerging evidence suggests B-cell receptor-associated protein 29 may modulate apoptosis and calcium homeostasis. Its interaction with the pro-apoptotic regulator BCL2 family proteins suggests that BCAP29 may act as a mediator between ER stress and mitochondrial signaling. The BCAP29 antibody allows researchers to study these molecular connections in models of neurodegeneration, immune activation, and cancer. \u003cbr\u003e\u003cbr\u003eThe BCAP29 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, producing characteristic perinuclear staining consistent with ER localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=BCAP29 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=BCAP29 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=BCAP29 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/BCAP29 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=BCAP29+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047288332653,"sku":"FY12433","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1edd3fc2-0a89-4a48-bb9f-a5a8004450ac.jpg?v=1782236996","url":"https:\/\/www.ebiohippo.com\/products\/bcap29-antibody-b-cell-receptor-associated-protein-29-bha17135336","provider":"BioHippo","version":"1.0","type":"link"}