{"product_id":"bcl6-antibody-b-cell-lymphoma-6-bha17135278","title":"BCL6 Antibody \/ B-cell lymphoma 6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eBCL6 Antibody \/ B-cell lymphoma 6 is a anti-BCL6 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e BCL6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe BCL6 antibody targets B-cell lymphoma 6 protein, a transcriptional repressor encoded by the BCL6 gene. B-cell lymphoma 6 plays a pivotal role in germinal center B-cell development, proliferation, and differentiation. As a zinc finger transcription factor, it modulates gene expression by recruiting corepressor complexes to DNA binding sites, silencing target genes involved in DNA damage response, apoptosis, and differentiation. The BCL6 antibody enables detection of this key transcriptional regulator, providing an essential reagent for immunology, oncology, and hematopathology research.\u003cbr\u003e\u003cbr\u003eB-cell lymphoma 6 is required for the formation and maintenance of germinal centers during immune responses. It represses genes such as TP53 and PRDM1 to allow B cells to proliferate and undergo somatic hypermutation without triggering apoptosis. The BCL6 antibody allows researchers to visualize this dynamic regulation in lymphoid tissues and cell lines, offering insight into B-cell maturation and immune system adaptation. BCL6 expression is transiently induced during the germinal center stage and subsequently downregulated as cells differentiate into plasma or memory B cells.\u003cbr\u003e\u003cbr\u003eAberrant BCL6 expression is implicated in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, where chromosomal translocations or mutations disrupt its normal regulation. These alterations lead to constitutive repression of target genes and uncontrolled proliferation. The BCL6 antibody serves as an important diagnostic and research tool for detecting abnormal expression in lymphoma biopsies and assessing therapeutic responses to BCL6 inhibitors. Its use in immunohistochemistry and western blotting allows pathologists to distinguish germinal center B-cell subtypes from activated or memory B cells.\u003cbr\u003e\u003cbr\u003eBeyond hematologic malignancies, B-cell lymphoma 6 influences other tissues by modulating inflammation, metabolism, and neural differentiation. In macrophages and T cells, it acts as a transcriptional repressor that controls cytokine production and immune tolerance. The BCL6 antibody enables studies of these non-lymphoid functions, expanding understanding of how this transcription factor integrates immune and metabolic signaling networks. Recent research also links BCL6 to cancer stem cell maintenance and chemoresistance in solid tumors, underscoring its broad biological significance.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=BCL6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=BCL6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=BCL6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/BCL6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=BCL6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047284728173,"sku":"FY12375","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fb134574-5197-4e48-a10e-f56e13f80b6e.jpg?v=1782236993","url":"https:\/\/www.ebiohippo.com\/products\/bcl6-antibody-b-cell-lymphoma-6-bha17135278","provider":"BioHippo","version":"1.0","type":"link"}