{"product_id":"beclin-1-antibody-bha11907995","title":"Beclin 1 Antibody","description":"\u003cp\u003eBeclin 1, the mammalian ortholog of yeast Atg6, is a key regulator of autophagy—a cellular degradation pathway essential for maintaining neuronal homeostasis. As a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex, Beclin 1 orchestrates autophagosome formation and maturation, processes critical for the clearance of damaged organelles and misfolded proteins.\u003c\/p\u003e\n\n\u003cp\u003eIn the nervous system, Beclin 1 plays a pivotal role in neurodevelopment and neuroprotection. Dysregulation of Beclin 1-mediated autophagy has been implicated in a range of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, where impaired protein clearance contributes to synaptic dysfunction and neuronal loss.\u003c\/p\u003e\n\n\u003cp\u003eBeclin 1 is primarily localized to cytoplasmic structures, including mitochondria, but overexpression studies have also revealed nuclear localization, suggesting additional regulatory roles. Notably, reduced Beclin 1 expression has been observed in the hippocampus of individuals with schizophrenia, linking autophagy deficits to psychiatric disorders.\u003c\/p\u003e\n\n\u003cp\u003eFurthermore, Beclin 1 may contribute to neuroimmune defense. It has been shown to protect against infection by neurovirulent strains of Sindbis virus, highlighting its role in antiviral responses within the central nervous system.\u003c\/p\u003e\n\n\u003cp\u003eGiven its multifaceted functions in autophagy, neurodevelopment, and immune defense, Beclin 1 is a promising target for therapeutic strategies aimed at restoring cellular homeostasis in neurodegenerative and neuropsychiatric disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040794599789,"sku":"SPC-600D","price":338.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040885006701,"sku":"SPC-600D-A390","price":393.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040885039469,"sku":"SPC-600D-A488","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040885072237,"sku":"SPC-600D-A594","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040885105005,"sku":"SPC-600D-APC","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040885137773,"sku":"SPC-600D-BI","price":388.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040885170541,"sku":"SPC-600D-FITC","price":383.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040885203309,"sku":"SPC-600D-HRP","price":378.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040885236077,"sku":"SPC-600D-PCP","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040885268845,"sku":"SPC-600D-RPE","price":389.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040885301613,"sku":"SPC-600S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-600-Beclin-1-Antibody-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png?v=1771832159","url":"https:\/\/www.ebiohippo.com\/products\/beclin-1-antibody-bha11907995","provider":"BioHippo","version":"1.0","type":"link"}