{"product_id":"beta-arrestin-1-antibody-bha17102620","title":"Beta Arrestin 1 Antibody","description":"\u003cp\u003eFunctions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt]\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In PBS with 50% glycerol and 0.03% ProClin 300 \/ 0.1 ml","offer_id":53042936709485,"sku":"F54014-0.1ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_aa5ab1c6-86b5-4317-b3b1-5ca9cb00e6bd.jpg?v=1771924040","url":"https:\/\/www.ebiohippo.com\/products\/beta-arrestin-1-antibody-bha17102620","provider":"BioHippo","version":"1.0","type":"link"}