{"product_id":"bi8626-bhb20407928","title":"BI8626","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eBI8626\u003c\/strong\u003e (CAS 1875036-75-1) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e1875036-75-1\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC25H28N8\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e440.54 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eN=1C=NC2=C(N=CN=C2N3CCN(CC=4C=CC=CC4)CC3)C1NCC=5C=CC=C(C5)CN\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eBI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD\/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e E1\/E2\/E3 Enzyme\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Ubiquitination\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"1 mg","offer_id":53327205106029,"sku":"T14569-1MG","price":84.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53327551168877,"sku":"T14569-5MG","price":198.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327551201645,"sku":"T14569-1MLX10MM","price":226.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327551234413,"sku":"T14569-10MG","price":289.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327551267181,"sku":"T14569-25MG","price":513.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327551299949,"sku":"T14569-50MG","price":728.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327551332717,"sku":"T14569-100MG","price":985.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":53327551365485,"sku":"T14569-200MG","price":1330.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEWayM6eEaySiAAAAAHk_6Dw099.png?v=1778722106","url":"https:\/\/www.ebiohippo.com\/products\/bi8626-bhb20407928","provider":"BioHippo","version":"1.0","type":"link"}