{"product_id":"bml-278-bhb11900137","title":"Bml-278","description":"\u003cp\u003eBML-278 is a selective, cell-permeable activator of SIRT1, a NAD⁺-dependent deacetylase involved in regulating cellular stress responses, metabolism, and aging. With high specificity for SIRT1 over SIRT2 and SIRT3, BML-278 enhances SIRT1 activity at low micromolar concentrations. In neuroscience, SIRT1 activation is associated with neuroprotection, improved mitochondrial function, and reduced neuroinflammation. SIRT1 modulates key transcription factors such as PGC-1α and FOXO, which are involved in oxidative stress resistance and neuronal survival. BML-278 is increasingly used in models of Alzheimer’s and Parkinson’s disease to investigate therapeutic strategies targeting age-related cognitive decline and neurodegenerative mechanisms.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040945267053,"sku":"SIH-349-5MG","price":77.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040962994541,"sku":"SIH-349-25MG","price":312.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-349_BML-278_SIRT1_activator_Chemical_Structure.png?v=1771837630","url":"https:\/\/www.ebiohippo.com\/products\/bml-278-bhb11900137","provider":"BioHippo","version":"1.0","type":"link"}