{"product_id":"bovine-vimentin-bhp11005142","title":"Bovine Vimentin","description":"\u003cp\u003e\u003cstrong\u003eBovine Vimentin\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eVimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo\/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038168572269,"sku":"pro-525-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038516633965,"sku":"pro-525-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"0.1 mg","offer_id":53038516666733,"sku":"pro-525-01MG","price":990.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-vimentin-bovine-PRO-525.png?v=1782158366","url":"https:\/\/www.ebiohippo.com\/products\/bovine-vimentin-bhp11005142","provider":"BioHippo","version":"1.0","type":"link"}