{"product_id":"bsg-antibody-cd147-bha17135435","title":"Bsg Antibody \/ CD147","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eBsg Antibody \/ CD147 is a anti-CD147 Rabbit antibody Recombinant Rabbit Monoclonal clone 30B80 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD147\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30B80, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eBSG antibody detects basigin, also known as CD147, an immunoglobulin superfamily member encoded by the BSG gene. Basigin is a transmembrane glycoprotein expressed in many tissues and cell types. It functions as a receptor and regulator of matrix metalloproteinases, monocarboxylate transporters, and extracellular signaling molecules. By modulating these pathways, basigin influences immune responses, metabolism, and tumor progression.\u003cbr\u003e\u003cbr\u003eBSG antibody is widely used in immunology, oncology, and infectious disease research. In cancer, basigin promotes tumor invasion and metastasis by inducing matrix metalloproteinase activity. It also regulates metabolic processes by facilitating lactate transport through interactions with monocarboxylate transporters. By detecting basigin, researchers can study how CD147 contributes to the tumor microenvironment and cellular metabolism.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, flow cytometry, immunohistochemistry, and immunofluorescence. In western blot assays, BSG antibody detects protein bands corresponding to basigin in multiple tissues. Flow cytometry enables quantitative assessment of CD147 expression on immune and tumor cells. Immunohistochemistry reveals tissue specific patterns, while immunofluorescence highlights subcellular localization at plasma membranes.\u003cbr\u003e\u003cbr\u003eBasigin also plays roles in immunity and infectious disease. It regulates leukocyte activation, T cell function, and pathogen interactions. Basigin has been identified as a receptor for certain parasites and viruses, linking it to infectious disease research. By using BSG antibody, scientists can evaluate the role of CD147 in host pathogen interactions and immune regulation.\u003cbr\u003e\u003cbr\u003eBSG antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD147 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD147 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD147 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD147 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD147+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047291740525,"sku":"FY12532","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f8791536-b31e-4ce8-bcd3-abc26e1b6939.jpg?v=1772019305","url":"https:\/\/www.ebiohippo.com\/products\/bsg-antibody-cd147-bha17135435","provider":"BioHippo","version":"1.0","type":"link"}