{"product_id":"bv-173-cell-bhc11100350","title":"BV-173 cell","description":"The BV-173 cell line originates from the peripheral blood of a patient diagnosed with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML), established in 1980. This cell line is particularly noted for its Ph+ status, which is indicative of a specific chromosomal abnormality involving the translocation between chromosome 9 and chromosome 22. This translocation, often referred to as the Philadelphia chromosome, results in the BCR-ABL fusion gene, a critical molecular hallmark that drives the pathogenesis of CML by promoting leukemic cell proliferation and survival.\n\nBV-173 cells are used extensively in hematological research as a model to study the cellular and molecular mechanisms of CML, especially in the context of drug resistance and the cellular response to tyrosine kinase inhibitors (TKIs), which target the BCR-ABL fusion protein. The cell line has been instrumental in preclinical studies for evaluating new therapeutic strategies and understanding the biology of CML. BV-173 exhibits characteristics typical of myeloid lineage cells and is often used to study signal transduction pathways that are deregulated in CML due to the BCR-ABL oncogene.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100350\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950199763309,"sku":"300133","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/bv-173-_282_29_1920x1920_f2b9040c-cf59-4be8-b1a1-ee29e36b3082.jpg?v=1769068970","url":"https:\/\/www.ebiohippo.com\/products\/bv-173-cell-bhc11100350","provider":"BioHippo","version":"1.0","type":"link"}