{"product_id":"cabp1-antibody-calcium-binding-protein-1-bha17135445","title":"CABP1 Antibody \/ Calcium binding protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCABP1 Antibody \/ Calcium binding protein 1 is a anti-CABP1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C60 supplied in Liquid format. Recommended for workflows such as Immunofluorescence (IF), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human, Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CABP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31C60, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IF, ICC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCABP1 antibody detects calcium binding protein 1, a neuronal calcium binding protein encoded by the CABP1 gene. CABP1 belongs to the calmodulin like protein family and contains EF hand domains that sense calcium signals. It regulates calcium channels, neurotransmitter release, and synaptic plasticity. CABP1 is predominantly expressed in brain and retina, where it modulates signaling events essential for neuronal communication and vision.\u003cbr\u003e\u003cbr\u003eCABP1 antibody is widely used in neuroscience and sensory biology research. CABP1 interacts with L type calcium channels and inositol 1,4,5 triphosphate receptors, tuning calcium signaling in neurons. It plays roles in learning, memory, and synaptic adaptation. In the retina, CABP1 modulates photoreceptor signaling and contributes to visual processing. By detecting CABP1, researchers can evaluate how neuronal calcium sensors shape cellular signaling.\u003cbr\u003e\u003cbr\u003e In western blot assays, CABP1 antibody detects protein bands corresponding to expected isoforms in neural tissue. Immunohistochemistry highlights expression in hippocampus and retina, while immunofluorescence reveals subcellular localization at synapses and dendrites. These methods support detailed analysis of calcium binding proteins in neurons.\u003cbr\u003e\u003cbr\u003eAltered CABP1 expression has been linked to neurological disorders including schizophrenia and epilepsy, where calcium signaling is disrupted. CABP1 also influences neuronal excitability and response to stress, suggesting broader roles in neuroprotection. By applying CABP1 antibody, scientists can investigate how calcium sensors contribute to brain function and disease mechanisms.\u003cbr\u003e\u003cbr\u003eCABP1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CABP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CABP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CABP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CABP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CABP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047291314541,"sku":"FY12542","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7c91355b-ca24-43ff-8315-bfb4596274e2.jpg?v=1772019307","url":"https:\/\/www.ebiohippo.com\/products\/cabp1-antibody-calcium-binding-protein-1-bha17135445","provider":"BioHippo","version":"1.0","type":"link"}