{"product_id":"cacna1a-antibody-calcium-voltage-gated-channel-subunit-alpha1-a-cav2-1-bha17135736","title":"CACNA1A Antibody \/ Calcium voltage-gated channel subunit alpha1 A \/ Cav2.1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCACNA1A Antibody \/ Calcium voltage-gated channel subunit alpha1 A \/ Cav2.1 is a anti-CACNA1A Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CACNA1A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCACNA1A antibody detects Calcium voltage-gated channel subunit alpha1 A (Cav2.1), a pore-forming subunit of the P\/Q-type voltage-dependent calcium channel complex that mediates calcium influx into excitable cells. The UniProt recommended name is Voltage-dependent P\/Q-type calcium channel subunit alpha-1A (CACNA1A). This channel plays a critical role in neurotransmitter release, synaptic plasticity, and neuronal excitability in the central nervous system. Cav2.1 channels are primarily localized at presynaptic terminals where they regulate vesicular fusion and exocytosis in response to membrane depolarization.\u003cbr\u003e\u003cbr\u003eThe CACNA1A gene, located on chromosome 19p13, encodes a large transmembrane protein that forms the channel's alpha1 subunit. This subunit contains four homologous domains, each with six membrane-spanning segments, creating a central pore through which calcium ions pass. The channel's function is modulated by auxiliary beta and alpha2delta subunits that influence its gating properties, trafficking, and kinetics. Through tightly controlled calcium entry, Cav2.1 channels couple electrical activity to intracellular signaling, shaping neuronal communication and network function.\u003cbr\u003e\u003cbr\u003ePhysiologically, CACNA1A is highly expressed in cerebellar Purkinje cells, brainstem nuclei, and cortical neurons. It is essential for proper motor coordination, synaptic transmission, and cerebellar function. In neurons, P\/Q-type calcium channels trigger the release of neurotransmitters such as glutamate, acetylcholine, and GABA, regulating synaptic strength and timing. CACNA1A activity is also implicated in dendritic calcium signaling and gene expression, linking membrane excitability to long-term neuronal adaptations.\u003cbr\u003e\u003cbr\u003eMutations in CACNA1A are associated with several neurological disorders, including familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2), and spinocerebellar ataxia type 6 (SCA6). These mutations alter channel gating or expression, leading to abnormal calcium signaling and disrupted neurotransmission. Research using CACNA1A antibody has contributed to understanding how Cav2.1 dysfunction leads to motor incoordination, seizure susceptibility, and neurodegeneration. The antibody is valuable for studying channel localization, expression regulation, and structure-function relationships in both normal and disease states.\u003cbr\u003e\u003cbr\u003eCACNA1A antibody is useful in immunohistochemistry, immunofluorescence, and related applications to detect neuronal calcium channels in brain and cultured neuron samples. It enables visualization of P\/Q-type channel distribution and contributes to studies of synaptic physiology and channelopathies.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CACNA1A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CACNA1A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CACNA1A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CACNA1A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CACNA1A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047302947181,"sku":"FY12834","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_24e5ab1a-5c7c-4c18-a7a8-01fe85005730.jpg?v=1782237052","url":"https:\/\/www.ebiohippo.com\/products\/cacna1a-antibody-calcium-voltage-gated-channel-subunit-alpha1-a-cav2-1-bha17135736","provider":"BioHippo","version":"1.0","type":"link"}