{"product_id":"calcineurin-a-antibody-bha17103825","title":"Calcineurin A Antibody","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eCalcineurin A antibody supplied as a ascites reagent for WB, IHC-P in Human, Mouse, Rat, Bovine samples. This product is a monoclonal (mouse origin) antibody (host: Mouse; isotype: Mouse IgG1) intended for research use only.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Monoclonal (mouse origin); host Mouse; isotype Mouse IgG1; clone CN-A1.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eFormat and purification:\u003c\/strong\u003e format: Ascites; purity: Ascites.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity (reported):\u003c\/strong\u003e Human, Mouse, Rat, Bovine.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e WB, IHC-P.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eImmunogen \/ epitope context:\u003c\/strong\u003e Bovine brain calcineurin was used as the immunogen for this Calcineurin A antibody..\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese attributes help you align the antibody with the biological question (target state, sample type, and readout) while keeping interpretation grounded in appropriate controls.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCalcineurin A is the intended antigen for this primary antibody. Reported biological context includes: Calcineurin, the Ca(2+)\/calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha(PPP3CA),is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase(calcineurin) catalytic subunit.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eSignal-flow and turnover studies: researchers pair immunodetection with perturbations that modulate enzymatic activity or proteostasis to understand regulation, stability, and feedback.\u003c\/li\u003e   \u003cli\u003eSpatial and single-cell approaches: imaging-based and cytometry workflows increasingly quantify heterogeneity and relocalization rather than only bulk abundance.\u003c\/li\u003e   \u003cli\u003eInteraction-centric biology: IP-based enrichment and proteomics are widely used to define complexes, binding partners, and context-specific interactomes.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eWestern blot (WB): compare relative abundance\/isoform patterns across conditions and sample types; band shifts may reflect processing or post-translational modification.\u003c\/li\u003e   \u003cli\u003eIHC-P: commonly used to measure relative target levels or localization changes in the context of the experimental question.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAcross these readouts, differences in signal intensity, localization, or complex enrichment are typically interpreted alongside sample-matched controls and independent evidence to distinguish regulation from technical variation.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eIsoforms, cleavage products, or post-translational modifications can alter apparent molecular weight and subcellular distribution; interpret bands and staining patterns in the context of expected biology and sample preparation.\u003c\/li\u003e   \u003cli\u003eSpecies differences and epitope conservation may affect binding; use matched positive controls and orthogonal evidence when comparing across organisms.\u003c\/li\u003e   \u003cli\u003eControl concepts: include appropriate isotype and secondary-only controls (for imaging), and consider genetic perturbations (knockout\/knockdown\/overexpression) or independent antibodies targeting distinct epitopes to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEpitope context is defined by the immunogen description; when available, align this with known domains, PTM sites, or family homology to anticipate potential cross-reactivity patterns. As a monoclonal antibody, binding is driven by a single epitope, which can support consistent recognition but may be sensitive to epitope masking by PTMs or conformational changes.\u003c\/p\u003e \u003c!-- Sources (internal): - UniProtKB entry (P63100) — UniProt Consortium — https:\/\/www.uniprot.org\/uniprotkb\/P63100\/entry - NCBI Gene search (Calcineurin A) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Calcineurin+A - Ensembl search (Calcineurin A) — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Calcineurin+A - PubMed search (Calcineurin A) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Calcineurin+A - Reactome pathway search (Calcineurin A) — Reactome — https:\/\/reactome.org\/content\/query?q=Calcineurin+A --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Lyophilized mouse ascites with 1% BSA and 0.01% sodium azide \/ 100 ug","offer_id":53043250463085,"sku":"R30007","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9733f5a7-28b2-4122-ba9d-defb54e3965a.jpg?v=1771934425","url":"https:\/\/www.ebiohippo.com\/products\/calcineurin-a-antibody-bha17103825","provider":"BioHippo","version":"1.0","type":"link"}