{"product_id":"calyculin-a-bhb21300069","title":"Calyculin A","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R, 7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9 ,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy -4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]de c-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethy lamino)-5-O-methyl-L-ribonamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 101932-71-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C50H81N4O15P.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO, ethanol, acetone, or methanol. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO, ethanol, acetone, or methanol. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Natural\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Calyculin A is a very potent, cell-permeable PP-1 and PP-2 inhibitor (IC50 = 2 nM and 0.5-1 nM respectively)1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003ePeptide confirmation\u003c\/h3\u003e \u003cp\u003eConfirmed by amino acid analysis and mass spectrometry\u003c\/p\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eCalyculin A was initially isolated from the marine sponge Discodermia calyx.1 It is a very potent, cell-permeable PP-1 and PP-2 inhibitor (IC50 2nM and 0.5-1nM respectively),2 and extremely specific for PP-1 and PP-2A among other acidic, alkaline and protein phosphatases.2,3\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"0.1 mg \/ 1","offer_id":53249707704685,"sku":"C-100-0P1MG-1","price":856.0,"currency_code":"USD","in_stock":true},{"title":"10 mcg \/ 1","offer_id":53311545311597,"sku":"C-100-10MCG-1","price":167.0,"currency_code":"USD","in_stock":true},{"title":"25 mcg \/ 1","offer_id":53311545344365,"sku":"C-100-25MCG-1","price":334.0,"currency_code":"USD","in_stock":true},{"title":"50 mcg \/ 1","offer_id":53311545377133,"sku":"C-100-50MCG-1","price":535.0,"currency_code":"USD","in_stock":true},{"title":"10 mcg \/ 5","offer_id":53311545409901,"sku":"C-100-10MCG-5","price":669.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C-100_str.gif?v=1778544418","url":"https:\/\/www.ebiohippo.com\/products\/calyculin-a-bhb21300069","provider":"BioHippo","version":"1.0","type":"link"}