{"product_id":"canine-transitional-cell-carcinoma-cell-line-ku-ctcc-002-bhc10902044","title":"Canine Transitional Cell Carcinoma Cell Line (KU-CTCC-002)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eThe KU-CTCC-002 cell line, originating from an 11-year-old Maltese dog's TCC tumor, carries the BRAF V595E mutation, underscoring its relevance in BRAF-targeted therapeutic research. It demonstrates MAPK pathway activation and a distinct response to BRAF inhibitors, with sorafenib showing pronounced efficacy over vemurafenib.\u003c\/p\u003e\n\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eModel identity:\u003c\/strong\u003e Canine Transitional Cell Carcinoma Cell Line (KU-CTCC-002) is supplied as a tumor cell line derived from Dog urinary tract.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth properties:\u003c\/strong\u003e Adherent, round to spindle\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth conditions:\u003c\/strong\u003e PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. PriGrow XXII Medium (TM122) + 10% FBS(Regular*) + 10 mM HEPES (TM058) + 2 mM L-Glutamine (G275) + 1% Penicillin\/Streptomycin Solution (G255), 37.0°C, 5% CO₂.*Do not heat-inactivate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProduct format:\u003c\/strong\u003e Frozen, BSL-2\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis cell-based model is generally used in urinary tract biology, phenotype comparison, and assay development studies. Donor\/background information is available for contextual interpretation.\u003c\/p\u003e\n\u003ch2\u003eBiological background\u003c\/h2\u003e\n\u003cp\u003eThe cell line's proliferation rate and tumorigenic ability, particularly its rapid tumor growth in xenograft models, highlight its utility in exploring cancer progression, drug resistance, and the evaluation of novel therapeutic agents for both canine and comparative oncology.Note: KU-CTCC-002 grows faster than KU-CTCC-001 (Cat. T8165) and KU-CTCC-001-LM3 (Cat. T8167) in xenograft models, suggesting it may offer unique insights into tumor growth dynamics and interaction with the microenvironment. It represents a separate patient origin, providing an opportunity to study inter-tumoral heterogeneity.Complete list of cell lines from this panel:Cat. T8165 - Canine Transitional Cell Carcinoma Cell Line (KU-CTCC-001)Cat. T8166 - Canine Transitional Cell Carcinoma Cell Line (KU-CTCC-002) Cat. T8167 - Canine Lymph Node Metastasis TCC Cell Line (KU-CTCC-001-LM3) Donor\/background information provided for this product: 11, Maltese, Transitional Cell Carcinoma.\u003c\/p\u003e\n\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCell-line models continue to be used for tumor phenotype comparison, pathway perturbation studies, and assay development in controlled in vitro systems.\u003c\/li\u003e\n\u003cli\u003eEngineered and subtype-defined tumor lines are often used to compare growth behavior, reporter output, and response patterns across matched experimental conditions.\u003c\/li\u003e\n\u003cli\u003eWhen metastatic or lineage features are described, investigators commonly interpret results alongside morphology, passage history, and culture environment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon research applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCancer biology studies that compare proliferation-associated behavior, morphology, and pathway responses in vitro.\u003c\/li\u003e\n\u003cli\u003eAssay development for treatment response, reporter monitoring, or phenotype comparison under matched culture conditions.\u003c\/li\u003e\n\u003cli\u003eSide-by-side comparison of engineered versus parental background characteristics when relevant to the study design.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eChanges in morphology, growth rate, viability, or reporter signal are typically interpreted together with passage history, culture matrix, and the specified growth conditions for the model.\u003c\/p\u003e\n\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMorphology, doubling behavior, and reporter or marker output can shift with passage number, substrate choice, and medium composition; these variables should be recorded alongside experimental readouts.\u003c\/li\u003e\n\u003cli\u003eMatched controls such as parental cells, untreated cultures, or parallel cultures maintained under identical conditions help distinguish background effects from biology of interest.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCulture and product details\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Conditions:\u003c\/strong\u003e PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. PriGrow XXII Medium (TM122) + 10% FBS(Regular*) + 10 mM HEPES (TM058) + 2 mM L-Glutamine (G275) + 1% Penicillin\/Streptomycin Solution (G255), 37.0°C, 5% CO₂.*Do not heat-inactivate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeeding Density (cells\/cm²):\u003c\/strong\u003e 40,000\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Applied Biological Materials (abm) Inc.","offers":[{"title":"1x10\u003csup\u003e6\u003c\/sup\u003e cells \/ 1.0 ml","offer_id":53180539240813,"sku":"T8166","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/xcGj0x88kpECi0pmAwVH4EfGYib4lrItNSlicWCU.png?v=1774957852","url":"https:\/\/www.ebiohippo.com\/products\/canine-transitional-cell-carcinoma-cell-line-ku-ctcc-002-bhc10902044","provider":"BioHippo","version":"1.0","type":"link"}