{"product_id":"cask-antibody-bha11933485","title":"RECOMBINANT CASK Antibody","description":"\u003cp\u003eCASK (calcium\/calmodulin-dependent serine protein kinase) is a ~112 kDa member of the membrane-associated guanylate kinase (MAGUK) family, functioning as a critical scaffolding protein in neuronal development and synaptic organization. Structurally, CASK integrates multiple signaling domains—including a CaMK-like kinase domain, SH3 domain, PDZ domain, and a guanylate kinase (GUK) homology domain—enabling it to anchor transmembrane proteins to the cytoskeleton and intracellular signaling complexes.\u003c\/p\u003e\n\n\u003cp\u003eIn the nervous system, CASK plays a pivotal role in stabilizing synaptic architecture by binding to neurexins at the presynaptic membrane, facilitating the assembly of pre- and postsynaptic structures. Beyond its cytoplasmic functions, a nuclear fraction of CASK translocates to the nucleus, where it acts as a transcriptional co-activator, influencing gene expression programs essential for neurodevelopment.\u003c\/p\u003e\n\n\u003cp\u003eLoss-of-function studies underscore CASK’s essential role: mice with CASK gene disruptions exhibit perinatal lethality, highlighting its necessity for survival. Additionally, CASK is expressed in non-neuronal tissues, including basal keratinocytes and developing hair follicles, suggesting broader roles in tissue development and wound repair.\u003c\/p\u003e\n\n\u003cp\u003eEmerging evidence links CASK dysfunction to neurodevelopmental and neurodegenerative disorders, including intellectual disability, microcephaly, and cerebellar atrophy. As a multifunctional regulator of synaptic integrity and gene expression, CASK is increasingly recognized as a key molecular target in neuroscience and neurodegeneration research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040796893549,"sku":"SMC-626D","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040904044909,"sku":"SMC-626D-A390","price":386.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040904077677,"sku":"SMC-626D-A488","price":385.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040904110445,"sku":"SMC-626D-A594","price":385.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040904143213,"sku":"SMC-626D-APC","price":384.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040904175981,"sku":"SMC-626D-BI","price":381.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040904208749,"sku":"SMC-626D-FITC","price":377.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040904241517,"sku":"SMC-626D-HRP","price":373.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040904274285,"sku":"SMC-626D-PCP","price":384.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040904307053,"sku":"SMC-626D-RPE","price":382.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040904339821,"sku":"SMC-626S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-626_Cask_Antibody_PT55_WB_Human_HEK293-OE-lysate_1.png?v=1771832173","url":"https:\/\/www.ebiohippo.com\/products\/cask-antibody-bha11933485","provider":"BioHippo","version":"1.0","type":"link"}