{"product_id":"casp6-antibody-caspase-6-bha17135656","title":"CASP6 Antibody \/ Caspase 6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCASP6 Antibody \/ Caspase 6 is a anti-CASP6 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C93 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CASP6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31C93, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCASP6 antibody detects caspase 6, a cysteine protease encoded by the CASP6 gene. Alternate identifiers include MCH2 and apoptotic cysteine protease 6. Caspase 6 belongs to the caspase family of cysteine aspartate proteases that orchestrate apoptosis and inflammation. Synthesized as an inactive proenzyme, caspase 6 undergoes autocatalytic processing or cleavage by upstream caspases to generate the active enzyme, which then cleaves specific substrates during programmed cell death.\u003cbr\u003e\u003cbr\u003eCASP6 antibody is widely applied in neuroscience, apoptosis research, and oncology. Caspase 6 activity contributes to neuronal apoptosis and axonal degeneration, with elevated activity linked to Alzheimer disease and Huntington disease. In cancer biology, caspase 6 mediates apoptosis in response to stress and chemotherapeutic drugs. By detecting caspase 6, researchers can examine apoptotic pathways and their dysregulation in disease.\u003cbr\u003e\u003cbr\u003e Western blot assays identify pro and cleaved caspase 6 isoforms, immunohistochemistry maps expression in tissues undergoing apoptosis, and immunofluorescence detects localization in neuronal and cancer cell models. These assays provide robust methods for analyzing apoptotic signaling pathways.\u003cbr\u003e\u003cbr\u003eCaspase 6 cleaves substrates such as lamin A and huntingtin, contributing to nuclear disassembly and neurodegeneration. Dysregulated activity promotes pathological cell death, while insufficient activity may contribute to impaired apoptosis in cancer. By applying CASP6 antibody, scientists can evaluate the balance of pro survival and pro death signals across systems.\u003cbr\u003e\u003cbr\u003eCASP6 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CASP6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CASP6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CASP6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CASP6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CASP6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047298851181,"sku":"FY12753","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_21573610-37ba-4783-a092-335e00dd684f.jpg?v=1772019340","url":"https:\/\/www.ebiohippo.com\/products\/casp6-antibody-caspase-6-bha17135656","provider":"BioHippo","version":"1.0","type":"link"}