{"product_id":"catechin-5-o-gallate-bhb21905398","title":"Catechin-5-O-gallate","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eNatural Products\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eCatechin-5-O-gallate is a flavan-3-ol gallate in which gallic acid is esterified to the 5-hydroxyl group of the catechin A-ring. The structure supplied has the (2R,3S) configuration of (+)-catechin, which distinguishes it from gallates of (−)-epicatechin such as epicatechin-3-O-gallate. It is listed among the bioactive constituents of traditional Himalayan medicinal plants.\u003c\/p\u003e\n\u003cp\u003eIn a computational study of Himalayan plant phytochemicals, molecular docking predicted that catechin-5-O-gallate binds the SARS-CoV-2 main protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp) and helicase, and in silico ADMET profiling predicted it to be a P-glycoprotein inhibitor\u003csup\u003e[1]\u003c\/sup\u003e. These are computational predictions; they were not tested experimentally in the cited work. The compound is suitable as a starting point for experimental validation of these predicted interactions and for structure–activity studies of galloylated catechins.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e128232-62-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC\u003csub\u003e22\u003c\/sub\u003eH\u003csub\u003e18\u003c\/sub\u003eO\u003csub\u003e10\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e442.37 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStereochemistry\u003c\/th\u003e\n\u003ctd\u003e(2R,3S) — (+)-catechin configuration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eO=C(C1=CC(O)=C(C(O)=C1)O)OC2=C3C(O[C@H](C4=CC(O)=C(C=C4)O)[C@H](C3)O)=CC(O)=C2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSynonyms\u003c\/th\u003e\n\u003ctd\u003e(+)-Catechin 5-gallate; (+)-Catechin 5-O-gallate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003eLot-specific; reported on the Certificate of Analysis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003eAnti-infection; Membrane Transporter\/Ion Channel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003ePlease store the product under the recommended conditions in the Certificate of Analysis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33915361\/\"\u003eNatesh J, et al. Promising phytochemicals of traditional Himalayan medicinal plants against putative replication and transmission targets of SARS-CoV-2 by computational investigation. Comput Biol Med. 2021;133:104383.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"50 mg","offer_id":54051818209645,"sku":"HY-183746-50MG","price":0.0,"currency_code":"USD","in_stock":false},{"title":"100 mg","offer_id":54051818242413,"sku":"HY-183746-100MG","price":0.0,"currency_code":"USD","in_stock":false},{"title":"250 mg","offer_id":54051818275181,"sku":"HY-183746-250MG","price":0.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGY7S12EOidyAAAAAP31eo0342.png?v=1778722075","url":"https:\/\/www.ebiohippo.com\/products\/catechin-5-o-gallate-bhb21905398","provider":"BioHippo","version":"1.0","type":"link"}