{"product_id":"cay10602-bhb20428575","title":"CAY10602","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eCAY10602\u003c\/strong\u003e (CAS 374922-43-7) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e374922-43-7\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC22H15FN4O2S\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e418.44 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eNC1=C(C2=NC3=C(C=CC=C3)N=C2N1C1=CC=C(F)C=C1)S(=O)(=O)C1=CC=CC=C1\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eCAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-kappaB-dependent induction of TNF-alpha by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 uM, without cytotoxicity.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e Sirtuin\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e DNA Damage\/DNA Repair, Chromatin\/Epigenetic\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"5 mg","offer_id":53327246917997,"sku":"T4062-5MG","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327553593709,"sku":"T4062-10MG","price":40.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327553626477,"sku":"T4062-1MLX10MM","price":44.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327553659245,"sku":"T4062-25MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327553692013,"sku":"T4062-50MG","price":163.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327553724781,"sku":"T4062-100MG","price":278.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGayHjuEZC4sAAAAAPpb5LI204.png?v=1778722212","url":"https:\/\/www.ebiohippo.com\/products\/cay10602-bhb20428575","provider":"BioHippo","version":"1.0","type":"link"}