{"product_id":"cbr1-antibody-carbonyl-reductase-1-bha17135804","title":"CBR1 Antibody \/ Carbonyl reductase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCBR1 Antibody \/ Carbonyl reductase 1 is a anti-CBR1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30C98 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CBR1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30C98, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCBR1 antibody detects Carbonyl reductase 1, encoded by the CBR1 gene. Carbonyl reductase 1 is an NADPH dependent enzyme that catalyzes the reduction of carbonyl containing compounds to their corresponding alcohols. This enzyme is part of the short chain dehydrogenase\/reductase family and has a broad substrate spectrum, including xenobiotics, endogenous prostaglandins, and pharmacological agents. CBR1 antibody provides a valuable tool for studying drug metabolism, detoxification, and cellular defense mechanisms against reactive carbonyl species.\u003cbr\u003e\u003cbr\u003eCarbonyl reductase 1 contributes to the metabolism of anthracycline drugs such as doxorubicin, converting them to less active alcohol metabolites. While this reduces anticancer activity, it also influences drug toxicity, particularly cardiotoxicity. Research with CBR1 antibody has been central to understanding interindividual variability in anthracycline metabolism and its impact on therapeutic outcomes. CBR1 also reduces prostaglandins and quinones, helping regulate inflammatory responses and oxidative stress signaling.\u003cbr\u003e\u003cbr\u003eCBR1 has been linked to cancer, cardiovascular disease, and neurodegeneration. Overexpression has been reported in several tumors, where it may promote resistance to chemotherapy. Conversely, genetic polymorphisms in the CBR1 gene influence enzymatic activity and alter susceptibility to drug side effects. Using CBR1 antibody, researchers have demonstrated its tissue specific expression, with high levels in liver, kidney, and heart, reflecting its role in systemic detoxification. These findings underscore the enzyme's dual role in both protecting tissues and modulating pharmacological efficacy.\u003cbr\u003e\u003cbr\u003eCBR1 antibody is applicable in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting demonstrates isoform expression across tissues, while immunohistochemistry reveals cytosolic distribution. Activity based assays combined with CBR1 antibody confirm enzyme function and response to inhibitors. These approaches allow detailed mapping of metabolic pathways influenced by Carbonyl reductase 1.\u003cbr\u003e\u003cbr\u003eBy providing validated CBR1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CBR1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CBR1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CBR1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CBR1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CBR1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047307207021,"sku":"FY12902","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2856b852-60b3-44da-b95f-07d29146251d.jpg?v=1782237067","url":"https:\/\/www.ebiohippo.com\/products\/cbr1-antibody-carbonyl-reductase-1-bha17135804","provider":"BioHippo","version":"1.0","type":"link"}