{"product_id":"ccr1-antibody-c-c-chemokine-receptor-type-1-bha17136241","title":"CCR1 Antibody \/ C-C chemokine receptor type 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCCR1 Antibody \/ C-C chemokine receptor type 1 is a anti-CCR1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CCR1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCCR1 antibody detects C-C chemokine receptor type 1, a G protein-coupled receptor (GPCR) encoded by the CCR1 gene on chromosome 3p21.31. CCR1 is a membrane receptor primarily expressed on monocytes, macrophages, neutrophils, and T lymphocytes, where it mediates chemotactic responses to inflammatory chemokines. As part of the beta chemokine receptor family, CCR1 plays a central role in immune cell trafficking, inflammation, and host defense. High expression levels are observed in bone marrow, spleen, and peripheral blood leukocytes, highlighting its function in immune surveillance and leukocyte migration.\u003cbr\u003e\u003cbr\u003eCCR1 binds multiple chemokines, including CCL3 (MIP-1alpha), CCL5 (RANTES), and CCL7 (MCP-3), triggering intracellular signaling cascades that guide immune cells toward infection or inflammation sites. Ligand binding activates G protein-mediated signaling through phospholipase C, PI3K, and MAPK pathways, resulting in cytoskeletal rearrangement, integrin activation, and chemotaxis. CCR1 also contributes to immune homeostasis by regulating leukocyte retention and activation in tissue microenvironments.\u003cbr\u003e\u003cbr\u003eStructurally, CCR1 consists of seven transmembrane alpha-helices characteristic of GPCRs, with extracellular loops for ligand recognition and an intracellular C-terminal tail that interacts with G proteins and regulatory kinases. CCR1 belongs to the C-C chemokine receptor family, which includes CCR2-CCR5, all mediating overlapping but distinct immune signaling profiles. Co-localization studies show CCR1 residing in lipid rafts and endocytic vesicles, allowing rapid receptor internalization and recycling after ligand stimulation.\u003cbr\u003e\u003cbr\u003eFunctionally, CCR1 regulates leukocyte trafficking during inflammation, autoimmune response, and hematopoiesis. It is critical for monocyte and neutrophil recruitment to sites of infection and tissue injury. The receptor also participates in bone remodeling by influencing osteoclast differentiation through CCL5 signaling. In the nervous system, CCR1 modulates neuroinflammation by controlling microglial migration and cytokine release.\u003cbr\u003e\u003cbr\u003eDysregulation of CCR1 contributes to various pathological conditions including rheumatoid arthritis, multiple sclerosis, and chronic obstructive pulmonary disease (COPD). Overexpression enhances leukocyte infiltration and tissue inflammation, whereas pharmacological inhibition of CCR1 has shown therapeutic potential in autoimmune and fibrotic disorders. Pathway involvement includes chemokine-mediated signaling, GPCR activation, and NF-kappaB inflammatory pathways. During development, CCR1 expression is upregulated in hematopoietic progenitors and inflammatory cells responding to infection.\u003cbr\u003e\u003cbr\u003eThe CCR1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CCR1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CCR1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CCR1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CCR1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CCR1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047323263341,"sku":"FY13339","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_dd7e9cdf-7e6e-4f37-acdf-8066d29401d3.jpg?v=1782237115","url":"https:\/\/www.ebiohippo.com\/products\/ccr1-antibody-c-c-chemokine-receptor-type-1-bha17136241","provider":"BioHippo","version":"1.0","type":"link"}