{"product_id":"ccrf-cem-cell-bhc11100304","title":"CCRF-CEM cell","description":"CCRF-CEM cells are a type of human T lymphoblasts commonly used in immuno-oncology and immunology research. These cells were isolated from the peripheral blood of a 4-year-old female Caucasian with acute lymphoblastic leukemia (ALL).\nCCRF-CEM grow in suspension and can reach high cell density when cultured in spinner flasks. Karyotype analysis of CCRF-CEM cells showed a modal number of 47 chromosomes, ranging from 41 to 95. They show no consistent loss or gain of specific chromosomes and no marker chromosomes. However, 28% of cells with 45 chromosomes showed C- and 53% of all cells had an extra D, and 35% had an additional F. \nCCRF-CEM cells are tumorigenic and can cause tumours in Syrian hamsters. These cells express CD3, CD5, CD7, and CD4 genes and antigens. Additionally, isoenzyme analysis showed ADA, 1; ES-D, 1; G6PD, B; GLO-I, 1; PEP-D, 1; PGD, C; PGM1, 1; PGM3, 0. These cells are reported to be free of virus particles as determined by electron microscopy.\nA study has shown that the combination of resveratrol and prednisolone induced apoptosis in CCRF-CEM cells in a time- and dose-dependent manner. The combination treatment showed synergistic effects on the overexpression of BAx and the downregulation of BCL2.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100304\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950200811885,"sku":"300147","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CCRF-CEM_20P1_2010x01_20170725_ch00_1920x1920_c2caf295-1c36-46b5-b952-831a963b2f4f.jpg?v=1769068986","url":"https:\/\/www.ebiohippo.com\/products\/ccrf-cem-cell-bhc11100304","provider":"BioHippo","version":"1.0","type":"link"}