{"product_id":"cd163l1-antibody-cd163-like-1-cd163b-bha17136063","title":"CD163L1 Antibody \/ CD163 like 1 \/ CD163b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCD163L1 Antibody \/ CD163 like 1 \/ CD163b is a anti-CD163L1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C59 supplied in Liquid format. Recommended for workflows such as Immunohistochemistry (IHC) with listed reactivity in Human. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD163L1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31C59, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCD163L1 antibody detects CD163 like 1 protein, also called CD163b, encoded by the CD163L1 gene. CD163 like 1 is a scavenger receptor expressed on subsets of monocytes and macrophages, structurally related to CD163 but with distinct ligand binding and immune functions. CD163L1 antibody provides researchers with a valuable tool to study macrophage biology, innate immunity, and inflammatory disease.\u003cbr\u003e\u003cbr\u003eCD163 like 1 is a member of the scavenger receptor cysteine-rich family and localizes to the plasma membrane of immune cells. Research using CD163L1 antibody has shown that this receptor binds hemoglobin haptoglobin complexes and other ligands, contributing to clearance of hemoglobin and modulation of inflammation. Unlike CD163, CD163L1 expression is restricted to specific immune cell subsets, suggesting specialized functions in innate defense.\u003cbr\u003e\u003cbr\u003eIn immune regulation, CD163L1 influences cytokine responses and macrophage polarization. Studies with CD163L1 antibody have demonstrated that its engagement alters production of pro- and anti-inflammatory mediators, shaping immune responses during infection and tissue repair. Dysregulation of CD163L1 expression has been associated with chronic inflammation and autoimmune disorders.\u003cbr\u003e\u003cbr\u003eBeyond immunity, CD163L1 has been implicated in cardiovascular and metabolic diseases. Research using CD163L1 antibody has revealed associations with atherosclerosis, where scavenger receptor activity influences lipid uptake and foam cell formation. In metabolic disease, altered expression may contribute to chronic low-grade inflammation in obesity and diabetes. These findings expand the role of CD163L1 beyond classical scavenger functions to systemic disease processes.\u003cbr\u003e\u003cbr\u003eCD163L1 antibody is applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting confirms protein size, immunohistochemistry shows tissue localization, and flow cytometry quantifies expression on immune subsets. These methods make CD163L1 antibody useful in immunology and pathology research.\u003cbr\u003e\u003cbr\u003eBy providing validated CD163L1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD163L1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD163L1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD163L1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD163L1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD163L1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047313400173,"sku":"FY13161","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_275e08e1-7f6b-4825-82ce-eff6c146c93a.jpg?v=1782237114","url":"https:\/\/www.ebiohippo.com\/products\/cd163l1-antibody-cd163-like-1-cd163b-bha17136063","provider":"BioHippo","version":"1.0","type":"link"}