{"product_id":"cd22-antibody-bl-cam-bha17136320","title":"CD22 Antibody \/ BL-CAM","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCD22 Antibody \/ BL-CAM is a anti-CD22 Rabbit antibody Recombinant Rabbit Monoclonal clone CBO-3 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human. Reported localization: Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD22\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone CBO-3, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCD22 (BL-CAM) is a B cell-specific transmembrane glycoprotein that functions as an inhibitory receptor, regulating B cell receptor (BCR) signaling. It belongs to the immunoglobulin superfamily and modulates B cell activation thresholds, helping maintain immune tolerance and prevent overactivation of the immune response.    \u003cp\u003eCD22 is primarily expressed on mature B cells and plays a role in B cell survival, adhesion, and migration within lymphoid tissues. Altered CD22 expression or function has been associated with autoimmune diseases and B cell malignancies, making it an important biomarker and therapeutic target in immunology and oncology research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality CD22 antibody enables sensitive detection in applications such as flow cytometry, immunohistochemistry, and western blot. A CD22 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD22 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD22 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD22 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD22 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD22+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325294957,"sku":"RQ8901","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_301119a7-90dd-4f89-8271-3034b722317a.jpg?v=1772019444","url":"https:\/\/www.ebiohippo.com\/products\/cd22-antibody-bl-cam-bha17136320","provider":"BioHippo","version":"1.0","type":"link"}