{"product_id":"cd244-antibody-natural-killer-cell-receptor-2b4-bha17136299","title":"Cd244 Antibody \/ Natural killer cell receptor 2B4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCd244 Antibody \/ Natural killer cell receptor 2B4 is a anti-CD244 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P, Direct ELISA with listed reactivity in Mouse, Rat. Reported localization: Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD244\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, Direct ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCD244 (also known as 2B4 or SLAMF4) is an immunoreceptor expressed on NK cells, CD8+ T cells, gamma delta T cells, monocytes, and some dendritic cells. It binds CD48 to modulate cytotoxicity, cytokine secretion, and immune synapse formation. Signal polarity (activating vs. inhibitory) depends on adaptor usage, including SAP\/SH2D1A and EAT-2, enabling context-specific tuning of effector function. The \u003cb\u003eCD244 antibody\u003c\/b\u003e helps delineate these pathways by resolving expression and activation states across cell subsets.\u003cp\u003eDysregulated CD244 signaling is linked to impaired NK function in chronic viral infection, T cell exhaustion in tumors, and altered myeloid responses. Expression level, phosphorylation status, and adaptor association serve as readouts for immune competence in immuno-oncology, vaccine studies, and autoimmunity research, making precise detection with the CD244 antibody valuable for mechanistic and translational investigations.\u003c\/p\u003e\n\u003cp\u003eThe CD244 antibody supports applications such as flow cytometry, immunohistochemistry, and western blot to quantify receptor abundance, track subcellular localization, and assess pathway modulation under genetic or pharmacologic perturbation. With high specificity and reproducible performance across primary cells and model systems, the CD244 antibody enables rigorous analysis of NK and T cell biology.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD244 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD244 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD244 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD244 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD244+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047325458797,"sku":"RQ8880","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_833cfb8c-e8de-4bb6-bfb5-d16baa23bed1.jpg?v=1772019442","url":"https:\/\/www.ebiohippo.com\/products\/cd244-antibody-natural-killer-cell-receptor-2b4-bha17136299","provider":"BioHippo","version":"1.0","type":"link"}