{"product_id":"cd36-antibody-platelet-glycoprotein-4-bha17136164","title":"CD36 Antibody \/ Platelet glycoprotein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCD36 Antibody \/ Platelet glycoprotein 4 is a anti-CD36 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Flow cytometry (FACS), Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD36\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e FACS, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCD36 antibody detects Platelet glycoprotein 4, a multifunctional membrane receptor involved in lipid metabolism, angiogenesis, inflammation, and immune regulation. The UniProt recommended name is Platelet glycoprotein 4 (CD36). This scavenger receptor binds a wide range of ligands, including oxidized low-density lipoproteins (oxLDL), long-chain fatty acids, thrombospondin, and collagen, linking metabolic and inflammatory signaling pathways.\u003cbr\u003e\u003cbr\u003eFunctionally, CD36 antibody identifies a 472-amino-acid glycoprotein expressed on the plasma membrane of platelets, macrophages, adipocytes, and endothelial cells. CD36 mediates fatty acid uptake and translocation across membranes, contributing to energy homeostasis and lipid storage. It also functions as a pattern recognition receptor in innate immunity, detecting oxidized lipids and apoptotic cells. Engagement of CD36 triggers signaling cascades involving Src-family kinases, MAPKs, and NF-kB, influencing inflammation, oxidative stress, and phagocytosis.\u003cbr\u003e\u003cbr\u003eThe CD36 gene is located on chromosome 7q21.11 and is expressed in a broad range of tissues, including heart, skeletal muscle, liver, and immune cells. Expression is regulated by transcription factors such as PPARgamma and LXR, which respond to lipid availability and metabolic stress. CD36 plays a central role in coordinating cellular responses to lipid signals and oxidative modification.\u003cbr\u003e\u003cbr\u003ePathologically, CD36 dysregulation contributes to atherosclerosis, insulin resistance, and metabolic syndrome. Overexpression in macrophages promotes foam cell formation and plaque development, while impaired expression leads to altered lipid uptake and cardiac dysfunction. In cancer, CD36 enhances metastatic potential by supporting lipid utilization in tumor cells. Research using CD36 antibody supports studies in lipid biology, cardiovascular disease, and metabolic signaling.\u003cbr\u003e\u003cbr\u003eCD36 antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cell surface receptors. \u003cbr\u003e\u003cbr\u003eStructurally, Platelet glycoprotein 4 consists of two transmembrane domains, a large extracellular glycosylated loop, and short cytoplasmic tails that mediate signal transduction. The receptor interacts with caveolin and other membrane components to form lipid raft-associated complexes. This antibody enables investigation of CD36's function in lipid metabolism, inflammation, and vascular biology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD36 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD36 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD36 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD36 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD36+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319036269,"sku":"FY13262","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f1710975-09ab-415c-8944-015b4c858c05.jpg?v=1782237067","url":"https:\/\/www.ebiohippo.com\/products\/cd36-antibody-platelet-glycoprotein-4-bha17136164","provider":"BioHippo","version":"1.0","type":"link"}