{"product_id":"cd39-antibody-entpd1-bha17136368","title":"CD39 Antibody \/ ENTPD1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCD39 Antibody \/ ENTPD1 is a anti-CD39 Rabbit antibody Recombinant Rabbit Monoclonal clone 17E43 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CD39\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 17E43, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCD39 antibody is a widely used reagent for studying immune regulation, purinergic signaling, and vascular biology. The encoded protein, CD39 (also known as ectonucleoside triphosphate diphosphohydrolase 1 or ENTPD1), is an ectoenzyme expressed on the surface of endothelial cells, immune cells, and platelets. CD39 hydrolyzes extracellular ATP and ADP into AMP, which can then be converted into adenosine by CD73. This ATP-adenosine pathway regulates inflammation, thrombosis, and tissue homeostasis by balancing proinflammatory and immunosuppressive signals.\u003cbr\u003e\u003cbr\u003eIn the immune system, CD39 plays an important role in controlling T cell and regulatory T cell activity. By reducing extracellular ATP levels and increasing adenosine production, CD39 dampens inflammatory responses and promotes immune tolerance. High CD39 expression on regulatory T cells contributes to their immunosuppressive capacity, making CD39 a focus of interest in autoimmune disease, transplantation, and cancer immunology. In the vascular system, CD39 helps prevent platelet aggregation and thrombosis by degrading platelet-activating nucleotides, thereby maintaining vascular health.\u003cbr\u003e\u003cbr\u003eDysregulation of CD39 expression or activity has been implicated in diverse diseases. Increased CD39 activity has been observed in tumors, where it contributes to immune evasion by creating an adenosine-rich, immunosuppressive microenvironment. Conversely, reduced CD39 function has been linked to heightened inflammation in autoimmune diseases and transplant rejection. These associations underscore CD39 as both a biomarker and a therapeutic target across multiple areas of biomedical research.\u003cbr\u003e\u003cbr\u003eAt the molecular level, CD39 is a transmembrane glycoprotein with two transmembrane domains and large extracellular loops that contain conserved apyrase motifs responsible for nucleotide hydrolysis. Its enzymatic activity is dependent on divalent cations such as calcium and magnesium. By regulating extracellular nucleotide concentrations, CD39 serves as a critical checkpoint in purinergic signaling pathways that influence vascular tone, immune cell communication, and tissue repair.\u003cbr\u003e\u003cbr\u003eThe CD39 antibody is commonly used in flow cytometry, western blotting, immunohistochemistry, and immunofluorescence to detect protein expression and distribution. These applications are valuable for research in immunology, oncology, and cardiovascular biology. For scientists investigating immune regulation, thrombosis, or purinergic signaling, the CD39 antibody provides a specific and dependable detection tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CD39 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD39 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD39 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CD39 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CD39+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047327162733,"sku":"RQ8950","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1cb800c7-0046-445f-91a1-37cb57148d27.jpg?v=1772019450","url":"https:\/\/www.ebiohippo.com\/products\/cd39-antibody-entpd1-bha17136368","provider":"BioHippo","version":"1.0","type":"link"}