{"product_id":"cd79a-apc-bha19900651","title":"CD79a APC","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCD79a APC is a Mouse monoclonal targeting CD79a, supplied as a APC format for FC workflows. It supports measurement of Human target expression in common experimental systems.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClone:\u003c\/strong\u003e ZL7-4 — consistent clone identity can support panel reproducibility and cross-study comparisons.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG1, k — informs selection of matched controls and secondary reagents when relevant.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e APC — enables direct detection in fluorescence-based assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHost species:\u003c\/strong\u003e Mouse — useful for panel design and control strategy planning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human — interpret staining in the context of species-specific sequence and expression differences.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKey specifications such as clone identity, isotype, and fluorophore conjugation help researchers align panel design, control selection, and instrument configuration with the biological question and sample type.\u003c\/p\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eCD79 consist of two proteins, namely CD79a and CD79b. CD79a recognizes the Ig-alpha protein, and CD79b recognizes the Ig-beta protein of the B-cell antigen component of the B-lymphocyte antigen receptor. The expression of CD79 precedes immunoglobulin (Ig) gene heavy-chain gene rearrangement and CD20 expression during B-cell ontogeny, making the detection of this antibody useful for determining B-cell lineage. Mouse anti Human CD79a antibody, clone ZL7-4, recognizes the human B-cell antigen receptor complex-associated protein alpha chain, also known as MB-1 membrane glycoprotein or CD79a and is one of Pan B cell marker.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eHigh-parameter immunophenotyping: combining CD79a with complementary lineage and activation markers to resolve complex cell states.\u003c\/li\u003e\n\u003cli\u003ePanel standardization and data comparability: increasing emphasis on consistent reagents, compensation-aware fluorophore choices, and shared gating strategies.\u003c\/li\u003e\n\u003cli\u003eIntegration with single-cell multi-omics: pairing surface marker profiling with transcriptomic or proteomic readouts to connect phenotype to function.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eFlow cytometry: quantify CD79a-positive populations and compare expression distributions across conditions or time points.\u003c\/li\u003e\n\u003cli\u003eCell sorting: enrich CD79a-defined subsets for downstream RNA\/protein assays or functional readouts.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eChanges in measured signal are typically interpreted in the context of cell subset frequency, activation\/differentiation state, and sample processing effects rather than as a standalone readout.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eFluorophore selection: consider brightness, spectral overlap, and instrument configuration; compensation and spillover can affect apparent population boundaries.\u003c\/li\u003e\n\u003cli\u003eBiology-driven confounders: activation state, differentiation, and isoform\/PTM variation can shift epitope accessibility and apparent expression.\u003c\/li\u003e\n\u003cli\u003eControl concepts: include matched isotype and fluorescence-minus-one (FMO) controls where appropriate, and interpret results alongside biological positive\/negative reference samples.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor antibody-based assays, monoclonal versus polyclonal format can influence epitope recognition breadth and signal consistency. Conjugated antibodies support direct detection and can simplify multicolor panel design when paired with appropriate controls and instrument settings.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase — UniProt — https:\/\/www.uniprot.org\/ - NCBI Gene — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - HGNC gene nomenclature — HUGO Gene Nomenclature Committee — https:\/\/www.genenames.org\/ - Flow cytometry basics — NIH\/NCI (overview resources) — https:\/\/www.cancer.gov\/research\/resources - High-dimensional cytometry overview — Nature Methods (journal) — https:\/\/www.nature.com\/nmeth\/ --\u003e","brand":"Caprico","offers":[{"title":"25 Tests","offer_id":53072772497773,"sku":"115144","price":110.0,"currency_code":"USD","in_stock":true},{"title":"100 Tests","offer_id":53072845177197,"sku":"115145","price":240.0,"currency_code":"USD","in_stock":true},{"title":"200 Tests","offer_id":53072845209965,"sku":"115146","price":405.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/20220421-CD79a-ZL7-4-APC-151SA1-20uL-PBMC-FV.jpg?v=1772634897","url":"https:\/\/www.ebiohippo.com\/products\/cd79a-apc-bha19900651","provider":"BioHippo","version":"1.0","type":"link"}