{"product_id":"cdk16-antibody-pctk1-pctaire1-bha17135373","title":"CDK16 Antibody \/ PCTK1 \/ PCTAIRE1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCDK16 Antibody \/ PCTK1 \/ PCTAIRE1 is a anti-CDK16 Rabbit antibody Recombinant Rabbit Monoclonal clone 29C70 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CDK16\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29C70, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCDK16 antibody recognizes cyclin dependent kinase 16, also called PCTK1, PCTAIRE1, a member of the cyclin dependent kinase family encoded by the CDK16 gene. Unlike classical CDKs that regulate cell cycle checkpoints, CDK16 plays roles in vesicle trafficking, neuronal signaling, and spermatogenesis. It contains a conserved kinase domain and unique regulatory regions that interact with cyclins and adaptor proteins. CDK16 is highly expressed in brain and testis, consistent with its specialized functions in neurotransmission and reproduction.\u003cbr\u003e\u003cbr\u003eCDK16 antibody is widely used in neuroscience and reproductive biology research. In neurons, CDK16 regulates exocytosis of synaptic vesicles, contributing to neurotransmitter release and synaptic plasticity. In germ cells, CDK16 supports spermatogenesis by modulating vesicular transport and cytoskeletal organization. Mutations or altered expression of CDK16 have been linked to intellectual disability, developmental delay, and reproductive disorders. By detecting CDK16, researchers can study how kinase signaling influences both neuronal communication and fertility.\u003cbr\u003e\u003cbr\u003eThe antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. In western blot assays, CDK16 antibody detects bands corresponding to expected isoforms, enabling quantitative comparisons across tissues. Immunohistochemistry demonstrates tissue localization in brain and testis, while immunofluorescence highlights cytoplasmic distribution in neurons and germ cells. ELISA applications allow measurement of CDK16 protein levels in experimental samples.\u003cbr\u003e\u003cbr\u003eBeyond physiology, CDK16 has been implicated in cancer. Elevated expression has been reported in breast, lung, and prostate carcinoma, where it contributes to proliferation, survival, and invasion. CDK16 modulates signaling pathways that intersect with tumor suppressor networks, suggesting its role as a driver of oncogenesis. By applying CDK16 antibody, scientists can evaluate how kinase dysregulation promotes tumor development and whether CDK16 serves as a therapeutic target or biomarker.\u003cbr\u003e\u003cbr\u003eCDK16 also participates in insulin secretion, immune responses, and cellular differentiation. Its broad influence highlights the importance of studying this kinase in diverse biological contexts. In experimental systems, CDK16 interacts with proteins that regulate exocytosis and endocytosis, linking it to fundamental processes of intracellular trafficking. This versatility makes CDK16 antibody a valuable reagent for both basic and translational research.\u003cbr\u003e\u003cbr\u003eCDK16 antibody offered by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CDK16 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CDK16 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CDK16 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CDK16 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CDK16+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047291150701,"sku":"FY12470","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_504f7803-fcc9-44a5-bc89-0d1505287b6d.jpg?v=1772019296","url":"https:\/\/www.ebiohippo.com\/products\/cdk16-antibody-pctk1-pctaire1-bha17135373","provider":"BioHippo","version":"1.0","type":"link"}