{"product_id":"cdkn2c-antibody-cyclin-dependent-kinase-inhibitor-2c-bha17135711","title":"CDKN2C Antibody \/ Cyclin-dependent kinase inhibitor 2C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCDKN2C Antibody \/ Cyclin-dependent kinase inhibitor 2C is a anti-CDKN2C Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CDKN2C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCDKN2C antibody detects Cyclin-dependent kinase inhibitor 2C, a member of the INK4 family of tumor suppressors that regulate cell cycle progression. Encoded by the CDKN2C gene on chromosome 1p32.3, this protein inhibits cyclin-dependent kinases CDK4 and CDK6, preventing phosphorylation of the retinoblastoma (RB) protein and blocking the G1-to-S phase transition. By enforcing this checkpoint, CDKN2C maintains proper cell cycle control and prevents uncontrolled proliferation in both normal and cancerous tissues.\u003cbr\u003e\u003cbr\u003eCDKN2C, also known as p18INK4C, is composed of ankyrin repeat domains that mediate specific binding to CDKs, thereby blocking their interaction with D-type cyclins. Through this inhibition, CDKN2C contributes to cell differentiation, growth arrest, and senescence. It is particularly active in hematopoietic, endocrine, and neural cells, where it coordinates cell cycle exit during differentiation.\u003cbr\u003e\u003cbr\u003eThe CDKN2C antibody is widely used in cancer biology, cell cycle regulation, and molecular pathology research to study proliferation control, checkpoint activation, and tumor suppression. Western blot analysis identifies a 19 kilodalton band corresponding to CDKN2C, while immunohistochemistry demonstrates nuclear staining in differentiated and quiescent cells. This antibody enables examination of INK4-mediated CDK inhibition and its effects on proliferation and differentiation pathways.\u003cbr\u003e\u003cbr\u003eLoss or downregulation of CDKN2C is associated with multiple cancers, including glioma, pituitary adenoma, and leukemia, often through deletion or promoter methylation. Conversely, overexpression can contribute to cell cycle arrest and growth suppression. The CDKN2C antibody provides a dependable tool for studying tumor suppressor networks and checkpoint control.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CDKN2C - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CDKN2C - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CDKN2C - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CDKN2C - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CDKN2C+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047301800301,"sku":"FY12809","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_50e06196-5b2b-44ae-b295-eb054d375299.jpg?v=1782237045","url":"https:\/\/www.ebiohippo.com\/products\/cdkn2c-antibody-cyclin-dependent-kinase-inhibitor-2c-bha17135711","provider":"BioHippo","version":"1.0","type":"link"}