{"product_id":"ceacam1-antibody-carcinoembryonic-antigen-related-cell-adhesion-molecule-1-bha17136183","title":"Ceacam1 Antibody \/ Carcinoembryonic antigen-related cell adhesion molecule 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCeacam1 Antibody \/ Carcinoembryonic antigen-related cell adhesion molecule 1 is a anti-CEACAM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CEACAM1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCEACAM1 antibody targets Carcinoembryonic antigen-related cell adhesion molecule 1, a transmembrane glycoprotein that mediates cell-cell adhesion, signal transduction, and immune regulation. The CEACAM1 gene belongs to the CEA family within the immunoglobulin superfamily and encodes multiple isoforms with long or short cytoplasmic tails. CEACAM1 is broadly expressed on epithelial cells, endothelial cells, and subsets of leukocytes, including activated T and B cells, natural killer cells, and neutrophils. The protein functions as both an adhesion molecule and an immune checkpoint regulator, participating in inhibitory signaling via its immunoreceptor tyrosine-based inhibitory motifs (ITIMs) present in the long cytoplasmic domain.\u003cbr\u003e\u003cbr\u003eCEACAM1 contributes to numerous physiological processes including tissue morphogenesis, angiogenesis, and modulation of inflammatory responses. Its expression at intercellular junctions facilitates homophilic and heterophilic interactions with other CEACAM family members, supporting epithelial integrity. In immune cells, CEACAM1 engagement downregulates T-cell activation and cytokine release, serving as a negative regulator of immune responses. Dysregulation of CEACAM1 signaling has been implicated in autoimmune disorders, infectious disease susceptibility, and tumor immune evasion. In cancer biology, CEACAM1 acts context-dependently: it may function as a tumor suppressor by maintaining epithelial polarity, yet also contributes to tumor metastasis and angiogenesis in certain malignancies.\u003cbr\u003e\u003cbr\u003eThe human CEACAM1 gene is located on chromosome 19q13.2 and spans over 9 exons. Its expression is transcriptionally controlled by cytokines such as interferon gamma and transforming growth factor beta, reflecting its integration into immune regulatory networks. Pathogen binding studies have shown that CEACAM1 serves as an entry receptor for several bacteria, including Neisseria species and Haemophilus influenzae, making it a target of interest in host-pathogen interaction research.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using CEACAM1 antibody demonstrates strong expression in liver, lung, and intestinal epithelia, with variable detection in tumors such as melanoma, colorectal carcinoma, and prostate cancer. CEACAM1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CEACAM1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CEACAM1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CEACAM1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CEACAM1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CEACAM1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320707437,"sku":"FY13281","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c37f6779-bb1e-4dd7-822e-d355230f3d10.jpg?v=1782237090","url":"https:\/\/www.ebiohippo.com\/products\/ceacam1-antibody-carcinoembryonic-antigen-related-cell-adhesion-molecule-1-bha17136183","provider":"BioHippo","version":"1.0","type":"link"}