{"product_id":"ceruloplasmin-antibody-cp-bha17135434","title":"Ceruloplasmin Antibody \/ CP","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCeruloplasmin Antibody \/ CP is a anti-CP Rabbit antibody Recombinant Rabbit Monoclonal clone 31C62 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31C62, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCeruloplasmin antibody detects ceruloplasmin, a copper binding glycoprotein encoded by the CP gene. Ceruloplasmin is synthesized in the liver and secreted into the plasma, where it carries more than 95 percent of circulating copper. It functions as a ferroxidase enzyme that oxidizes Fe2 plus to Fe3 plus, enabling iron binding to transferrin. Through this activity, ceruloplasmin maintains systemic iron and copper balance, supports antioxidant defense, and regulates oxidative stress.\u003cbr\u003e\u003cbr\u003eCeruloplasmin antibody is widely applied in studies of metabolism, neurodegeneration, and inflammatory disease. Abnormal ceruloplasmin levels are associated with Wilson disease, aceruloplasminemia, and other disorders of copper metabolism. In addition, altered expression occurs in Parkinson disease and Alzheimer disease, where oxidative stress contributes to pathogenesis. By detecting ceruloplasmin, researchers can evaluate copper homeostasis and its links to neurological disorders.\u003cbr\u003e\u003cbr\u003e In western blot assays, ceruloplasmin antibody detects protein bands of the expected size in serum and liver extracts. Immunohistochemistry highlights hepatocyte production and distribution in tissues, while ELISA applications support quantification of ceruloplasmin levels in plasma. These methods make ceruloplasmin antibody useful for both clinical and experimental research.\u003cbr\u003e\u003cbr\u003eCeruloplasmin also acts as an acute phase reactant, with levels rising during inflammation and infection. Elevated ceruloplasmin is observed in autoimmune disease, cardiovascular disease, and cancer. By applying ceruloplasmin antibody, scientists can study how changes in CP expression reflect inflammation and metabolic stress.\u003cbr\u003e\u003cbr\u003eCeruloplasmin antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047292297581,"sku":"FY12531","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_08a7a335-1b91-4390-800b-4cceb00e5044.jpg?v=1772019303","url":"https:\/\/www.ebiohippo.com\/products\/ceruloplasmin-antibody-cp-bha17135434","provider":"BioHippo","version":"1.0","type":"link"}