{"product_id":"chicken-yolk-immunoglobulin-bhp10506083","title":"Chicken Yolk Immunoglobulin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative chicken immunoglobulin Y (IgY) is purified from chicken egg yolk and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Immunoglobulin\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eCommon names \/ aliases:\u003c\/strong\u003e IgY\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eIgY is the major serum and egg-yolk immunoglobulin in birds and the functional analog of mammalian IgG. Its structural differences from IgG can reduce cross-reactivity with mammalian Fc receptors and complement pathways, which is useful in certain assay designs.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse of avian antibodies in immunoassays to reduce interference from mammalian Fc-binding proteins and rheumatoid factor-like effects.\u003c\/li\u003e \u003cli\u003eAntigen-specific IgY generation and purification workflows for RUO applications in immunology and microbiology.\u003c\/li\u003e \u003cli\u003eComparative immunology studies exploring how avian and mammalian antibody systems differ in effector mechanisms.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eReference reagent for assay development where avian vs mammalian immunoglobulin behavior is compared.\u003c\/li\u003e \u003cli\u003eControls in workflows that require an avian immunoglobulin background (e.g., egg-yolk derived materials).\u003c\/li\u003e \u003cli\u003eAnalytical benchmarks for antibody purification and characterization methods.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eIgY does not behave identically to IgG in Fc-dependent interactions; interpret downstream effects accordingly.\u003c\/li\u003e \u003cli\u003eAs with other native immunoglobulins, polyclonality and glycosylation heterogeneity can affect binding readouts.\u003c\/li\u003e \u003cli\u003eMatrix carryover from yolk-derived preparations can influence some assays; use appropriate controls.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=IgY avian immunoglobulin - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IgY avian immunoglobulin - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IgY avian immunoglobulin%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052973613421,"sku":"CSB-NP004101C-1G","price":2500.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052973646189,"sku":"CSB-NP004101C-100MG","price":500.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052973678957,"sku":"CSB-NP004101C-10MG","price":200.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052973711725,"sku":"CSB-NP004101C-1MG","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP004101C-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/chicken-yolk-immunoglobulin-bhp10506083","provider":"BioHippo","version":"1.0","type":"link"}