{"product_id":"chiisanogenin-bhb21903077","title":"Chiisanogenin","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eNatural Products\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eChiisanogenin is a triterpenoid that is orally active. It lowers postprandial blood glucose by promoting GLUT4 translocation and glucose uptake through activation of the IRS-1\/PI3K\/Akt pathway, and it binds MLKL to block its phosphorylation and oligomerization, preserving lysosomal integrity, restoring autophagic flux, and suppressing NLRP3 inflammasome activation and pyroptosis. It also inhibits xanthine oxidase activity, regulates oxidative stress and ion pump activity, and binds to or inhibits PKA, H+\/K+-ATPase and β-glucuronidase. The compound displays broad-spectrum antibacterial, anticancer, anti-inflammatory, antirheumatic, renoprotective, cardioprotective and antiarrhythmic activity, and can be used in research on type 2 diabetes, rheumatoid arthritis, myocardial injury, hepatocellular carcinoma and ventricular arrhythmia\u003csup\u003e[1][2][3][4][5][6][7][8][9][10]\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eIt has the molecular formula C30H44O5 and a molecular weight of 484.68 g\/mol.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e89353-99-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC30H44O5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e484.68 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure Classification\u003c\/th\u003e\n\u003ctd\u003eSteroids\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eC[C@]12[C@]3([C@](C)([C@H](C(C)=C)CC1)[C@H](O)CC(=O)O[C@@]3(C[C@]4([C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([C@H](C(C)=C)CC5)[H])[H])[H])[H]\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget\u003c\/th\u003e\n\u003ctd\u003eNLRP3, GLUT4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003ePI3K\/Akt\/mTOR; Immunology\/Inflammation; Apoptosis; Stem Cell\/Wnt; TGF-beta\/Smad; Membrane Transporter\/Ion Channel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eInitial Source\u003c\/th\u003e\n\u003ctd\u003ePlant — Araliaceae Acanthopanax senticosus (Rupr. et Maxim.) Harms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003ePlease store the product under the recommended conditions in the Certificate of Analysis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description and in the In Vitro \u0026amp; In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40554287\"\u003eKwon EB, et al. Chiisanogenin enhances glucose uptake and lowers blood glucose via insulin signaling activation. Biomedicine \u0026amp; pharmacotherapy = Biomedecine \u0026amp; pharmacotherapie. 2025 Aug;189:118281.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [2]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15707776\"\u003eJung HJ, et al. Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freund's complete adjuvant-induced rats. Journal of ethnopharmacology. 2005 Feb 28;97(2):359-67.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [3]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42226649\"\u003eQu S, et al. Chiisanogenin Targets MLKL to Restore Autophagy and Suppress Pyroptosis in Renal Ischemia-Reperfusion Injury. Journal of agricultural and food chemistry. 2026 Jun 10;74(22):17099-17128.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [4]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11379786\"\u003eBae EA, et al. Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities. Biological \u0026amp; pharmaceutical bulletin. 2001 May;24(5):582-5.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [5]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12568356\"\u003eLee S, et al. Antibacterial compounds from the leaves of Acanthopanax senticosus. Archives of pharmacal research. 2003 Jan;26(1):40-2.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [6]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21046686\"\u003eYang C, et al. Determination and pharmacokinetic study of chiisanogenin in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry. Phytochemical analysis: PCA. 2011;22(3):225-9.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [7]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33188566\"\u003eWang H, et al. Potential Myocardial Protection of 3,4-seco-Lupane Triterpenoids from Acanthopanax sessiliflorus Leaves. Chemistry \u0026amp; biodiversity. 2021 Jan;18(1):e2000830.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [8]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33183092\/\"\u003eWang H, et al. Cytotoxic and anti-tumor effects of 3,4-seco-lupane triterpenoids from the leaves of Eleutherococcus sessiliflorus against hepatocellular carcinoma. Nat Prod Res. 2022 Feb;36(4):1062-1066.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [9]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38710375\"\u003eLiu Y, et al. Triterpenoids from the leaves of Eleutherococcus sessiliflorus, and their antiproliferative activities in TNF-α induced HFLS-RA cells. Phytochemistry. 2024 Jul;223:114133.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [10]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33615691\"\u003eZhao Y, et al. Protective Effects of 3,4-Seco-Lupane Triterpenes from Food Raw Materials of the Leaves of Eleutherococcus Senticosus and Eleutherococcus Sessiliflorus on Arrhythmia Induced by Barium Chloride. Chemistry \u0026amp; biodiversity. 2021 Apr;18(4):e2001021.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"50 mg","offer_id":67604977877357,"sku":"HY-N20708-50MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":67605494661485,"sku":"HY-N20708-100MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":67605494694253,"sku":"HY-N20708-250MG","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hy-n20708.gif?v=1790973138","url":"https:\/\/www.ebiohippo.com\/products\/chiisanogenin-bhb21903077","provider":"BioHippo","version":"1.0","type":"link"}