{"product_id":"cho-ctla4-cell-bhc11101488","title":"CHO-CTLA4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.\nThe CHO-CTLA4 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 3,000 molecules per cell. This cell line was created using an innovative landing pad technology that facilitates the targeted integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is a critical immune checkpoint protein found primarily on T-cells. It functions by competing with CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, leading to the downregulation of T cell activation. This mechanism is vital for maintaining immune self-tolerance and preventing autoimmunity. CTLA4's role in modulating immune responses has made it a significant target in cancer immunotherapy, particularly in immune checkpoint blockade strategies.\nThe expression of CXCR7 in this cell line was confirmed using flow cytometry.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101488\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950201303405,"sku":"305414","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/cho-hd_1920x1920_8414bae3-ee9f-42ef-bb53-1cda0600a649.jpg?v=1769068991","url":"https:\/\/www.ebiohippo.com\/products\/cho-ctla4-cell-bhc11101488","provider":"BioHippo","version":"1.0","type":"link"}