{"product_id":"ciq-bhb21300088","title":"CIQ","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 486427-17-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e (3-Chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C26H26ClNO5.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-20 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO up to 100 mM. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NMDA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e CIQ is an NR2C and NR2D selective potentiator of NMDA receptors. It enhances receptor responses two-fold with EC50 of 3 µM by increasing channel opening frequency1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e (3-Chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eCIQ is a positive allosteric potentiator selective for NR2C- and NR2D-containing N-methyl-d-aspartate (NMDA) receptors. The compound does not potentiate other NMDA receptor subtypes or AMPA and kainate receptors. The activity of CIQ depends on a single residue in the M1 region of the receptor1,2. CIQ demonstrates potentiating EC50 values of 2.7 and 2.8 μM for NR2C- and NR2D-containing receptors, respectively1.NMDA receptors are tetrameric entities composed of two obligatory GluN1 and two GluN2 subunits. They play important roles in numerous cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. NMDA receptors also mediate physiological functions such as learning and memory formation. They are also involved in many neurodegenerative conditions including Alzheimer's disease2,3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249708360045,"sku":"C-275-10MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311557042541,"sku":"C-275-100MG-1","price":611.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311557075309,"sku":"C-275-25MG-1","price":235.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311557108077,"sku":"C-275-5MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311557140845,"sku":"C-275-50MG-1","price":383.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C-275_gr.gif?v=1778544419","url":"https:\/\/www.ebiohippo.com\/products\/ciq-bhb21300088","provider":"BioHippo","version":"1.0","type":"link"}