{"product_id":"cirbp-antibody-cold-inducible-rna-binding-protein-bha17136327","title":"CIRBP Antibody \/ Cold-inducible RNA-binding protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCIRBP Antibody \/ Cold-inducible RNA-binding protein is a anti-CIRBP Rabbit antibody Recombinant Rabbit Monoclonal clone 26C38 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CIRBP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 26C38, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCold-inducible RNA-binding protein (CIRBP) is a stress-response protein that binds to RNA and modulates mRNA stability and translation. It is upregulated in response to mild hypothermia, ultraviolet radiation, and other cellular stressors, helping to regulate gene expression under challenging environmental conditions.    \u003cp\u003eCIRBP plays roles in cell proliferation, circadian rhythm regulation, and protection against apoptosis. It has been implicated in processes such as spermatogenesis, inflammation, and tumor progression. Altered CIRBP expression or function can influence cellular stress adaptation and disease development, making it a valuable target for molecular and biomedical research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality CIRBP antibody allows precise detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A CIRBP antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CIRBP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CIRBP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CIRBP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CIRBP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CIRBP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325163885,"sku":"RQ8908","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f9eac293-f150-43ff-aab8-2ad7766b6c23.jpg?v=1772019445","url":"https:\/\/www.ebiohippo.com\/products\/cirbp-antibody-cold-inducible-rna-binding-protein-bha17136327","provider":"BioHippo","version":"1.0","type":"link"}