{"product_id":"clobenpropit-dihydrobromide-bhb21300097","title":"Clobenpropit dihydrobromide","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 3-(1H-imidazol-5-yl)propyl N'-[(4-chlorophenyl)methyl]carbamimidothioate;dihydrobromide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e VUF 9153\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 145231-35-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C14H19Br2ClN4S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Histamine H3, Histamine H4, NMDA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Clobenpropit dihydrobromide is a potent and selective antagonist\/inverse agonist of the histamine H3 receptors (pA2 = 9.93), with partial agonist activity at histamine H4 receptors1. It is also an antagonist of the NMDA receptors (IC50 1 µM - 14 µM)2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e VUF 9153\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eClobenpropit dihydrobromide (VUF 9153) is a synthetic compound that acts as a potent, selective and competitive antagonist of the histamine H3 receptor and shows partial agonist activity towards the histamine H4 receptor. In addition, the compound acts as an antagonist of N-Methyl-d-aspartate (NMDA) receptors1 and displays IC50 values of 1 µM-14 µM2.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2\/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke, and mediate physiological functions such as learning and memory formation and participates in glutamate excitotoxicity2. Histamine H3 receptors are presynaptic G-protein coupled receptors that are expressed in the central nervous system. They regulate the release of several neurotransmitters, including biogenic amines, acetylcholine, GABA and glutamate3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249706754413,"sku":"C-345-10MG-1","price":184.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311551996269,"sku":"C-345-25MG-1","price":366.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311552029037,"sku":"C-345-5MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311552061805,"sku":"C-345-50MG-1","price":509.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C-345_gr.gif?v=1778544417","url":"https:\/\/www.ebiohippo.com\/products\/clobenpropit-dihydrobromide-bhb21300097","provider":"BioHippo","version":"1.0","type":"link"}