{"product_id":"clu-antibody-clusterin-bha17136105","title":"Clu Antibody \/ Clusterin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eClu Antibody \/ Clusterin is a anti-Clu Rabbit antibody Recombinant Rabbit Monoclonal clone 30C68 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Clu\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30C68, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eClu antibody detects Clusterin, encoded by the CLU gene. Clusterin is a secreted glycoprotein with diverse functions in lipid transport, apoptosis, and complement regulation. Also known as apolipoprotein J, Clusterin has been studied extensively in neurodegeneration, cancer, and reproductive biology. Clu antibody provides researchers with a versatile reagent to study cell survival, immune regulation, and disease processes.\u003cbr\u003e\u003cbr\u003eClusterin is expressed in many tissues and exists in secreted and nuclear forms. Research using Clu antibody has shown that secreted Clusterin acts as an extracellular chaperone, binding misfolded proteins and preventing aggregation. This function is particularly important in the brain, where Clusterin helps clear amyloid proteins associated with neurodegenerative disease. Nuclear Clusterin, in contrast, has been linked to pro-apoptotic signaling, underscoring its context-dependent roles.\u003cbr\u003e\u003cbr\u003eIn neurobiology, Clusterin is associated with Alzheimer's disease and other dementias. Studies with Clu antibody have demonstrated that increased Clusterin levels correlate with amyloid deposition and cognitive decline. Genome-wide association studies have identified CLU variants as risk factors for Alzheimer's disease, further highlighting its importance in neurodegeneration. As a result, Clusterin is being studied as both a biomarker and a therapeutic target.\u003cbr\u003e\u003cbr\u003eClusterin also plays important roles in cancer biology. Research using Clu antibody has revealed that secreted Clusterin can protect tumor cells from stress and apoptosis, promoting therapeutic resistance. Conversely, nuclear Clusterin may enhance apoptosis and suppress tumor growth. These opposing roles reflect the complex regulation of CLU expression and processing in cancer.\u003cbr\u003e\u003cbr\u003eClusterin has additional roles in reproduction, lipid transport, and complement regulation. Studies with Clu antibody have shown that it binds to sperm membranes and influences fertility, while also participating in complement inhibition during inflammation. Its broad functional repertoire makes it a protein of interest across multiple biological disciplines.\u003cbr\u003e\u003cbr\u003eClu antibody is widely used in western blotting, immunohistochemistry, ELISA, and immunofluorescence. Western blotting identifies multiple isoforms, immunohistochemistry reveals expression in brain and tumors, and ELISA quantifies soluble Clusterin in biological fluids. These applications make Clu antibody valuable for translational research.\u003cbr\u003e\u003cbr\u003eBy providing validated Clu antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Clu - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Clu - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Clu - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Clu - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Clu+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047318020461,"sku":"FY13203","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2346ec93-33f6-40af-98a0-f1378abdd944.jpg?v=1772019406","url":"https:\/\/www.ebiohippo.com\/products\/clu-antibody-clusterin-bha17136105","provider":"BioHippo","version":"1.0","type":"link"}