{"product_id":"co-102862-bhb21300078","title":"Co 102862","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e V102862\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 181144-66-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C14H12FN3O2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;96% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-200 μM\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NaV Na+ channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel1. IC50 values are 0.28-15.9 µM in rat hippocampal neurons2. It is an anticonvulsant, demonstrating potent activity in rodent models of tonic\/clonic and partial-complex seizures3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e V102862\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003ePeptide confirmation\u003c\/h3\u003e \u003cp\u003eConfirmed by amino acid analysis and mass spectrometry\u003c\/p\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eVoltage-gated Na+ channels play key roles in determining neuronal excitability1,2. Voltage- and use-dependent blockage of voltage-gated Na+ channels appear to be important in the mechanism of action of many anticonvulsants (e.g. phenytoin (PHT), carbamazepine (CBZ) and lamotrigine (LTG)), local anesthetics (e.g. lidocaine and bupivacaine) and Class I antiarrhythmics3-10.Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel11. IC50 values are 0.28-15.9 μM in rat hippocampal neurons11.Co 102862 is an anticonvulsant, demonstrating potent activity in rodent models of tonic\/clonic and partial-complex seizures12.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249705574765,"sku":"C-160-10MG-1","price":111.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311554322797,"sku":"C-160-25MG-1","price":188.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311554355565,"sku":"C-160-5MG-1","price":75.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311554388333,"sku":"C-160-50MG-1","price":335.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C-160_gr.gif?v=1778544409","url":"https:\/\/www.ebiohippo.com\/products\/co-102862-bhb21300078","provider":"BioHippo","version":"1.0","type":"link"}