{"product_id":"cpt2-antibody-carnitine-o-palmitoyltransferase-2-bha17136361","title":"CPT2 Antibody \/ Carnitine O-palmitoyltransferase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCPT2 Antibody \/ Carnitine O-palmitoyltransferase 2 is a anti-CPT2 Rabbit antibody Polyclonal (rabbit origin) supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P, Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasmic (Mitochondria), nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CPT2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCPT2 antibody is a widely used reagent for studying fatty acid metabolism, mitochondrial function, and energy homeostasis. The encoded protein, carnitine O-palmitoyltransferase 2 (CPT2), is a key enzyme in the carnitine shuttle system that transports long-chain fatty acids into mitochondria for beta-oxidation. Located on the inner mitochondrial membrane, CPT2 catalyzes the conversion of acylcarnitine back to acyl-CoA, enabling fatty acids to undergo oxidation and generate ATP. This function makes CPT2 essential for energy production, particularly during fasting, exercise, and other metabolic stresses.\u003cbr\u003e\u003cbr\u003eCPT2 operates in close coordination with CPT1, which resides on the outer mitochondrial membrane, and carnitine-acylcarnitine translocase (CACT), which shuttles acylcarnitines across the inner membrane. Together, these enzymes form a highly regulated system ensuring the efficient use of fatty acids as fuel. By facilitating long-chain fatty acid oxidation, CPT2 contributes to metabolic flexibility, energy balance, and cellular survival under nutrient-limited conditions.\u003cbr\u003e\u003cbr\u003eGenetic defects in the CPT2 gene are the cause of carnitine palmitoyltransferase II deficiency, a rare inherited metabolic disorder. Clinical presentations include lethal neonatal forms, severe infantile hepatocardiomuscular disease, and the most common myopathic form characterized by recurrent episodes of muscle weakness, rhabdomyolysis, and myoglobinuria. These conditions highlight the indispensable role of CPT2 in energy metabolism and underscore its clinical significance. Mutations affecting CPT2 disrupt fatty acid oxidation, leading to impaired ATP production and accumulation of toxic lipid intermediates.\u003cbr\u003e\u003cbr\u003eIn addition to its metabolic importance, CPT2 has been implicated in broader biological processes, including thermogenesis and regulation of lipid signaling pathways. Research has also linked altered CPT2 activity to metabolic syndromes, insulin resistance, and susceptibility to muscle-related disorders. Its central role in lipid utilization makes CPT2 a critical subject of investigation in both basic and translational research.\u003cbr\u003e\u003cbr\u003eThe CPT2 antibody is widely applied in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to measure protein expression, localization, and regulation. These applications are useful for assessing mitochondrial metabolism, characterizing genetic deficiencies, and exploring therapeutic approaches for metabolic disease. For researchers focused on lipid metabolism, muscle biology, or mitochondrial disorders, the CPT2 antibody provides a reliable detection tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CPT2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CPT2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CPT2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CPT2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CPT2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327228269,"sku":"RQ8943","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e40cf426-7bd6-4e4d-807a-2b30b2a9896e.jpg?v=1772019450","url":"https:\/\/www.ebiohippo.com\/products\/cpt2-antibody-carnitine-o-palmitoyltransferase-2-bha17136361","provider":"BioHippo","version":"1.0","type":"link"}