{"product_id":"crcp-antibody-cgrp-receptor-component-protein-bha17135965","title":"CRCP Antibody \/ CGRP receptor component protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCRCP Antibody \/ CGRP receptor component protein is a anti-CRCP Rabbit antibody Recombinant Rabbit Monoclonal clone 30C57 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CRCP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30C57, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCRCP antibody detects CGRP receptor component protein, encoded by the CRCP gene. This protein is a cytosolic and membrane associated component that is essential for functional signaling of calcitonin gene related peptide (CGRP) receptors. CRCP interacts with calcitonin receptor like receptor and receptor activity modifying proteins to stabilize receptor complexes and couple them to intracellular signaling. CRCP antibody provides researchers with a critical tool for investigating neuropeptide signaling, vascular regulation, and pain pathways.\u003cbr\u003e\u003cbr\u003eCGRP is a neuropeptide involved in vasodilation, pain transmission, and neurogenic inflammation. Functional CGRP receptors require three components: calcitonin receptor like receptor, a receptor activity modifying protein, and CRCP. Research using CRCP antibody has shown that CRCP is required for coupling receptor activation to downstream signaling through G proteins and adenylyl cyclase. Without CRCP, receptor complexes fail to properly signal, underscoring its essential role as a scaffolding factor in peptide receptor function.\u003cbr\u003e\u003cbr\u003eCRCP has been extensively studied in the context of migraine. CGRP is a well established mediator of migraine attacks, and antagonists of CGRP receptors have been developed as effective migraine therapies. Studies with CRCP antibody have confirmed that CRCP expression levels influence receptor signaling efficiency, making it an important determinant of migraine susceptibility and treatment response. Because CGRP signaling also regulates vascular tone, CRCP plays a role in cardiovascular homeostasis as well.\u003cbr\u003e\u003cbr\u003eBeyond migraine, CRCP contributes to nociception, inflammation, and central nervous system function. Research with CRCP antibody has demonstrated that reduced expression impairs neuronal responses to CGRP, while overexpression amplifies vasodilatory and inflammatory signaling. Its expression in vascular smooth muscle and neuronal tissue highlights its dual roles in vascular biology and sensory processing. Dysregulation of CRCP may therefore contribute to both neurological and cardiovascular disease.\u003cbr\u003e\u003cbr\u003eCRCP antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms expression in neuronal and vascular tissues, immunohistochemistry highlights its distribution in smooth muscle and brain, and immunofluorescence demonstrates colocalization with receptor partners. These approaches make CRCP antibody a versatile tool for examining receptor assembly, neuropeptide signaling, and disease mechanisms.\u003cbr\u003e\u003cbr\u003eBy supplying validated CRCP antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CRCP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CRCP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CRCP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CRCP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CRCP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047311466861,"sku":"FY13063","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_417e04ae-6e26-44aa-9f48-3645209b4cd2.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/crcp-antibody-cgrp-receptor-component-protein-bha17135965","provider":"BioHippo","version":"1.0","type":"link"}